Comparative Evaluation of the Antidiabetic Effects of Different Parts of Cassia fistula Linn, a Southeast Asian Plant

Table 6

Effect of methanolic and aqueous bark, leaf, and flower extracts of Cassia fistula on serum hepatic enzymes in diabetic rats.

Group	AST (IU)	ALT (IU)	ALP (IU)
Normal control	99.25±5.28	30.05±1.35	74.6±3.53
Diabetic control	128.4±4.52	44.23±1.70	132.8±2.69
Glibenclamide (2.5 mg/kg)	96.82 ± 2.66^c	34.11 ± 2.31^b	80.68 ± 4.16^c
BME 250 mg/kg	110.1±4.86	37.6±3.17	94.53 ± 2.74^c
BAE 250 mg/kg	119.5±5.84	38.25±2.62	112.6 ± 3.17^b
BME 500 mg/kg	100.8 ± 3.61^b	34.56 ± 1.26^a	85.43 ± 2.93^c
BAE 500 mg/kg	119.8±5.84	37.18±2.50	96.25 ± 3.34^c
LME 250 mg/kg	122.9±5.93	38.79±1.54	100.1 ± 4.05^c
LAE 250 mg/kg	122.1±5.27	40.53±1.25	123.1±3.15
LME 500 mg/kg	117.5±5.84	35.85 ± 2.54^a	89.27 ± 3.03^c
LAE 500 mg/kg	121.1±4.18	39.22±1.49	118.1 ± 2.79^a
FME 250 mg/kg	124 ± 4.87	39.14±2.62	125.7±3.57
FAE 250 mg/kg	124.3±4.79	40.7±1.27	126.4±2.98
FME 500 mg/kg	120.4±5.39	38.13±1.40	108.4 ± 5.32^c
FAE 500 mg/kg	122.5±5.84	39.52±1.13	122.9±3.38

Values are mean ± SEM (𝑛=6).
𝑃 value: ^a<0.05, ^b<0.01, ^c<0.001 as compared with diabetic control group (by one-way ANOVA followed by Dunnett’s multiple comparison test).