Optimizing Liposomal Cisplatin Efficacy through Membrane Composition Manipulations

<table>Cisplatin half-life (■) and the corresponding percent of increased lifespan (%ILS) (gray square) from the P388 murine lymphocytic leukemia model are plotted as a function of the liposomal membrane composition. Mice (<i>n</i> = 8) bearing P388 tumors received intravenous injections of liposomal cisplatin formulations at MTD doses on a Q4D × 3 dosing schedule.</table>

Chemotherapy Research and Practice

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Figure 3

Figure 3: Optimizing Liposomal Cisplatin Efficacy through Membrane Composition Manipulations 