Optimizing Liposomal Cisplatin Efficacy through Membrane Composition Manipulations
Figure 4
Accumulation of platinum in the spleen (a), liver (b), and kidneys (c) of BDF-1 mice (n = 3, Mean ± SD) following the injection of cisplatin at 3 mg/kg as free drug (■); liposomal cisplatin DSPC : DSPG : CHOL (7 : 2 : 1) (light-gray square), or liposomal cisplatin DSPC : DPPC : DSPG : CHOL (35 : 35; 20 : 10) (dark-gray square).