Review Article
Current Chemotherapeutic Management of Patients with Gestational Trophoblastic Neoplasia
Table 3
Treatment protocols for stage I gestational trophoblastic neoplasia (New England Trophoblastic Disease Center).
| Initial | Sequential MTX/ACT-D | Hysterectomy (with adjunctive single-agent chemotherapy) |
| Resistant to both single-agents | MAC | EMACO, if MAC fails | Hysterectomy (with adjunctive multiagent chemotherapy) | Local uterine resection (for localized lesion, to preserve, fertility) |
| Followup | 12 consecutive months of normal hCG levels | Contraception mandatory |
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ACT-D: actinomycin D; EMACO: etoposide, methotrexate, actinomycin D, cytoxan, oncovin; MAC: methotrexate, actinomycin D, cytoxan; MTX: methotrexate.
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