Neurotoxicity Caused by the Treatment with Platinum Analogues

Table 1

Comparison of cisplatin- and oxaliplatin-induced neurotoxicity	Cisplatin	Oxaliplatin
Dose limiting toxicity	Peripheral neurotoxicity	Peripheral neurotoxicity
Symptoms	Paresthesia	Paresthesia, sensory ataxia, and dysesthesia
Location	Extremities	Extremities, perioral area
Time-course onset	Delayed	Acute and delayed
After treatment	deterioration	Recovery
Accompanying toxicities	Ototoxicity	Laryngospasms
Precipitating factors	None	Exposure to cold