Integrin Signaling in Cancer Cell Survival and Chemoresistance

Figure 4

Model for collagen I/α2β1-mediated inhibition of drug-induced apoptosis in malignant T cells. Ligation of α2β1 integrin activates the MAPK/ERK, which blocks doxorubicin-induced RANKL expression. In turn, this leads to the reduction of cytochrome c release from the mitochondria and to the subsequent reduction of caspase activation and apoptosis.