Dermatologic Toxicities from Monoclonal Antibodies and Tyrosine Kinase Inhibitors against EGFR: Pathophysiology and Management

Table 2

MASCC skin toxicity group proposed rash staging (papulopustular eruption, grading individually for face, scalp, chest, or back).

Grade 1	Grade 1A: papules or pustules <5; OR 1 area of erythema or edema <1 cm in size
	Grade 1B: papules or pustules <5; OR 1 area of erythema or edema <1 cm in size AND pain or pruritis
Grade 2	Grade 2A: papules or pustules 6–20; OR 2–5 areas of erythema or edema <1 cm in size
	Grade 2B: papules or pustules 6–20; OR 2–5 areas of erythema or edema <1 cm in size AND pain, pruritus, or effect on emotions or functioning
Grade 3	Grade 3A: papules or pustules >20; OR more than 5 areas of erythema or edema <1 cm in size
	Grade 3B: papules or pustules >20; OR more than 5 areas of erythema or edema <1 cm in size; AND pain, pruritus, or effect on emotions or functioning