Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance

<table>IGF-IR signaling pathway. Increased expression of IGF-IR, or IGF-IR interaction and crosstalk with HER2 have been reported in models of Herceptin resistance. PI3K signaling has been implicated as a potential mechanism of IGF-IR-mediated Herceptin resistance. Inhibition of IGF-IR has been shown to increase sensitivity to Herceptin in preclinical studies.</table>

Chemotherapy Research and Practice

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Figure 2

Figure 2: Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance 