The Use of Epidermal Growth Factor Receptor Monoclonal Antibodies in Squamous Cell Carcinoma of the Head and Neck

Table 1

Anti-EGFR monoclonal antibodies in clinical use.

Antibody	Species	IgG	Activate ADCC*	Skin reactions
Cetuximab	Chimeric human/mouse	IgG1	Y	Y
Panitumumab	Fully human	IgG2	N	Mild
Zalutumumab	Fully human	IgG1	Y	Y
Nimotuzumab	Humanized	IgG1	Y	N
Matuzumab	Humanized	IgG1	Y	Mild

∗ADCC: antibody-dependent cellular cytotoxicity.