Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles
Figure 5
Relative changes in body weight in C57Bl/6 mice. (a) Oxaliplatin was injected i.v. every fourth day, four administrations in total, at a dose of (▲) 2 mg, (■) 4 mg, and (◆) 6 mg oxaliplatin/kg body weight. (b) DACHPt/cl-micelles were injected at identical treatment schedule at a dose of () 2 mg, (□) 4 mg, and (◊) 6 mg DACHPt/kg body weight. Dextrose 5% treatment (⚫) was used as the control. Values are mean ± standard deviation ().
