Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles

Table 1

Physicochemical properties of DACHPt/cl-micelles^a.

	𝐷eff; (nm)	PDI^b	ζ-potential; (mV)	LC^c; (%)	LE^d; (%)
Empty cl-micelles	170 ± 20	0.12	−38 ± 8	n.a	n.a
DACHPt/cl-micelles	154 ± 10	0.10	−30 ± 5	25	45

^aValues determined at pH 7.0, values are mean ± standard deviation.
^bPDI: polydispersity index.
^cLC: loading capacity (percentage of drug by weight incorporated into drug loaded cl-micelles), 𝑅=0.5.
^dLE: loading efficiency (percentage of drug incorporated into cl-micelles for a given amount of drug added to the mixture), 𝑅=0.5.