Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles

Table 3

Clinical chemistry parameters from female C57Bl/6 mice^a.

Treatment	ALT	AST	BUN	Creatinine
	(U/L)	(U/L)	(mg/dL)	(mg/dL)
Normal range^b	17–77		9–33	0.1–0.4
Control	26 ± 2.6	83 ± 8	13.3 ± 2.1	0.250±0.053
		Oxaliplatin
2 mg/kg	29 ± 1.4	82 ± 27.6	14.7 ± 4	0.160 ± 0.017 ^c
4 mg/kg	32 ± 2.5	110 ± 47.5 ^c	13.0 ± 1.0	0.157 ± 0.015 ^c
6 mg/kg	30 ± 1.0	88 ± 13.1	12.0 ± 1.7	0.160 ± 0.010 ^b
	DACHPt/cl-micelles
2 mg/kg	45 ± 2.1 ^c	149 ± 21.9 ^c	12.0 ± 2.0	0.230±0.046
4 mg/kg	63 ± 3.0 ^c	181 ± 36.9 ^c	8.7 ± 0.6	0.203±0.021
6 mg/kg	43 ± 29.0	143 ± 51.6	10.7 ± 2.9	0.170±0.044

^aValues are mean ± standard deviation (𝑛=3).
^bAs reported by Roy et al. [20]
^cSignificantly different from the controls (𝑃<0.05).