Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles

Table 4

Tissue weight analysis at sacrifice from female C57Bl/6 mice^a.

Treatment	Liver/BW	Spleen/BW	Kidney/BW
Control	0.0448 ± 0.0039	0.0041 ± 0.0013	0.0142 ± 0.0007
	Oxaliplatin
2 mg/kg	0.0418 ± 0.0013	0.0028 ± 0.0007	0.0131 ± 0.0006
4 mg/kg	0.0469 ± 0.0021	0.0021 ± 0.0003	0.0126 ± 0.0007 ^b
6 mg/kg	0.0459 ± 0.0025	0.0022 ± 0.0000	0.0130 ± 0.0004 ^b
	DACHPt/cl-micelles
2 mg/kg	0.0471 ± 0.0041	0.0037 ± 0.0005	0.0140 ± 0.0007
4 mg/kg	0.0542 ± 0.0025 ^b	0.0040 ± 0.0007	0.0153 ± 0.0003
6 mg/kg	0.0461 ± 0.0048	0.0038 ± 0.0005	0.0152 ± 0.0004

^aValues are mean ± standard deviation (𝑛=3).
^bSignificantly different from the controls (𝑃<0.05).