Clinical Study

A Postauthorization Survey to Document the Therapeutic Management of Oxaliplatin as a First-Line Chemotherapy Regimen in South Africa in Patients with Metastatic Colorectal Cancer

Table 1

Patient demographics and baseline clinical characteristics.

CharacteristicNumber of patients (%)

Sex
 Male122 (63)
 Female73 (37)
Age (years)
 Median62
 Mean60
 Range24–88
ECOG performance status
 Grade 063 (32)
 Grade 186 (44)
 Grade 210 (5)
 Grade 32 (1)
 Grade 40
 Unknown34 (17)
Neuropathy grade
 Grade 0182 (93)
 Grade 112 (6)
 Grade 20
 Grade 31 (1)
 Grade 40
Initial pathology type
 Adenocarcinoma192 (99)
 Mucinous colloid54 (28)
 Signet ring3 (2)
 Other*3 (2)
Sites of metastases
 Liver139 (71)
 Lung49 (25)
 Lymph node47 (24)
 Brain1 (0.5)
 Bone8 (4)
 Peritoneum20 (10)
 Other35 (18)
Histology
 Poorly differentiated20 (10)
 Moderately differentiated137 (70)
 Well differentiated9 (5)
 Unknown29 (15)
Tumour markers
 CEA
  Within range 0–5 ng/mL38 (20)
  Above range98 (50)
  Unknown59 (30)
 CA
  Within range 0–37 u/mL41 (21)
  Above range55 (28)
  Unknown99 (51)
 Past or present medical history excluding colorectal cancer
  Negative57 (29)
  Positive138 (71)
 Surgical history relevant to colorectal cancer
  Negative20 (10)
  Positive175 (90)
 Previous exposure to chemotherapy for colorectal cancer
  Negative157 (80)
  Positive 38 (20)
   Single16 (9)
   Mayo14 (7)
   Other8 (4)

The percentages are calculated out of the total survey’s cohort of 195 patients. Totals are occasionally above 195 due to multiple reporting for example initial pathology type and number of metastases.
ECOG: Eastern cooperative oncology group; CEA: carcinoembryonic antigen; CA: cancer antigen.
*Including infiltrated lymph around veins, moderate to poor differentiated, nonspecified.
Laboratory tests included full blood count, liver function test, and urea and electrolytes, of which only a few are listed here.
“Single” agents included 5-FU, fluroblastin, or Xeloda; “Mayo” included 5-FU and leucovorin or 5-FU and Rescuvolin or ABIC fluorouracil and Isovorin; “Other” included FOLFIRI, FOLFIRI with bevacizumab, FOLFIRI followed by Capecitabine, XELOX, and FOLFIRI with mitomycin, Tomudex, and capecitabine. Of those patients who received chemotherapy for colorectal cancer prior to this study, 28 (74%) patients received the chemotherapy in the adjuvant setting.