Chemotherapy Research and Practice / 2014 / Article / Tab 7 / Clinical Study
A Postauthorization Survey to Document the Therapeutic Management of Oxaliplatin as a First-Line Chemotherapy Regimen in South Africa in Patients with Metastatic Colorectal Cancer Table 7 Presence of neuropathy on the FOLFOX and XELOX regimens.
Cycle FOLFOX grade neuropathy per cycle (%) XELOX grade neuropathy per cycle (%) Total grade neuropathy per cycle All All All Grade 1 Grade 2 Grade 3 Grade 4 Cycle 1 5/118 (4.2) 4/62 (6.5) 12/195 9 2 1 — Cycle 2 30/114 (26.3) 13/59 (22.0) 52/185 46 5 1 — Cycle 3 47/109 (43.1) 15/52 (28.8) 69/170 60 8 1 — Cycle 4 53/104 (51) 13/48 (27.1) 73/161 60 11 2 — Cycle 5 55/99 (55.6) 13/42 (31) 73/149 58 14 1 — Cycle 6 53/96 (55.2) 10/34 (29.4) 69/138 49 14 4 2 Cycle 7 51/84 (60.7) 6/21 (28.6) 58/109 45 11 2 — Cycle 8 49/80 (61.3) 6/15 (40) 57/99 45 11 1 — Cycle 9 50/76 (65.8) 2/3 (66.7) 53/83 43 9 1 — Cycle 10 43/70 (61.4) 0/2 (0) 44/75 32 9 3 — Cycle 11 47/66 (71.2) 2/2 (100) 50/70 30 17 3 — Cycle 12 42/60 (70) 2/2 (100) 46/64 26 11 9 — Cycle 13 5/9 (55.6) 1/2 (50) 6/11 5 1 — — Cycle 14 3/7 (42.9) 1/2 (50) 5/9 3 — 2 — Cycle 15 1/2 (50) 1/1 (100) 2/3 1 1 — — Cycle 16 2/2 (100) 0/1 (0) 2/3 — 2 — — Cycle 17 2/2 (100) 2/2 — 2 — — Cycle 18 2/2 (100) 2/2 — 2 — — Cycle 19 1/1 (100) 1/1 — 1 — — Cycle 20 1/1 (100) 1/1 — 1 — — Cycle 21 1/1 (100) 1/1 — 1 — — Cycle 22 1/1 (100) 1/1 — 1 — — Total 544 89 679 (100%) 512 (75%) 134 (19.7%) 31 (4.6%) 2 (0.3%)
