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Cholesterol
Volume 2010 (2010), Article ID 824813, 4 pages
http://dx.doi.org/10.1155/2010/824813
Clinical Study

Influence of Soy Lecithin Administration on Hypercholesterolemia

1Department of Pharmacy, Camilo Castelo Branco University, Rua Carolina Fonseca 584-Itaquera, 08230-030 São Paulo, SP, Brazil
2Department of Pharmacy, Santo Amaro University, R Isabel Schmidt 339, 04743-030 São Paulo, SP, Brazil
3Health and Biological Sciences Department, Mackenzie Presbiterian University, Rua da Consolação 896, Campus São Paulo, 01302-907 São Paulo, SP, Brazil
4Department of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas (FCM-Unicamp), Rua Tessália Vieira de Camargo 126, Campinas-São Paulo, P.O. Box 6111, 13083-970 São Paulo, SP, Brazil

Received 24 July 2009; Accepted 4 October 2009

Academic Editor: W. Gibson Wood

Copyright © 2010 Amouni Mohamed Mourad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recent studies suggest that lecithin-rich diet can modify cholesterol homeostasis and hepatic lipoprotein metabolism. Considering the phytotherapeutic impact of lecithin, this work hypothesizes that lecithin administration in hypercholesterolemic patients may reduce cholesterol concentrations by increasing biliary secretion. Total cholesterol and LDL were evaluated after soy lecithin administration in hypercholesterolemic patients. One soy lecithin capsule (500 mg/RP-Sherer) was administrated daily. One-two months before the treatment beginning, blood samples were collected for total lipids and cholesterol fractions analysis. The results showed a reduction of 40.66% and 42.00% in total cholesterol and of 42.05% and 56.15% in LDL cholesterol after treatment for one and two months, respectively. A significant reduction in total cholesterol and LDL-cholesterol concentrations was observed during the first month of treatment, suggesting that the administration of soy lecithin daily may be used as a supplemental treatment in hypercholesterolemia.