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Cholesterol
Volume 2011 (2011), Article ID 274629, 7 pages
http://dx.doi.org/10.1155/2011/274629
Review Article

Friend Turns Foe: Transformation of Anti-Inflammatory HDL to Proinflammatory HDL during Acute-Phase Response

1Tata Proteomics and Coagulation Unit, Thrombosis Research Institute, Bangalore, India
2Narayana Hrudayalaya Hospital, Bangalore, India
3Thrombosis Research Institute, London, UK

Received 31 August 2010; Accepted 1 November 2010

Academic Editor: Jeffrey Cohn

Copyright © 2011 Hima Bindu G et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

High-density lipoprotein (HDL) is a major carrier of cholesterol in the blood. Unlike other lipoproteins, physiological functions of HDL influence the cardiovascular system in favorable ways except when HDL is modified pathologically. The cardioprotective mechanism of HDL is mainly based on reverse cholesterol transport, but there has been an emerging interest in the anti-inflammatory and antioxidant roles of HDL. These latter activities of HDL are compromised in many pathological states associated with inflammation. Further, abnormal HDL can become proinflammatory contributing to oxidative damage. In this paper, we discuss the functional heterogeneity of HDL, how alterations in these particles in inflammatory states result in loss of both antioxidant activity and reverse cholesterol transport in relation to atherosclerosis, and the need for assays to predict its functionality.