Review Article

Comparative Structures and Evolution of Vertebrate Carboxyl Ester Lipase (CEL) Genes and Proteins with a Major Role in Reverse Cholesterol Transport

Figure 4

Gene structures for the human and mouse CEL genes. Derived from AceView website http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/ [2]; the major isoform variant is shown with capped 5′- and 3′- ends for the predicted mRNA sequences; introns and exons are numbered; the length of the mRNAs (as kilobases or kb) and comparative expression levels with the average gene are shown; a CpG island (CpG51); several predicted transcription factor binding sites; and a MiRNA485-5p binding site were identified for the human CEL gene; the direction for transcription is shown; 3′UTR refers to 3′-untranslated region.
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