Table 1: Vertebrate CEL, human and mouse carboxylesterase (CES1–5) and nematode CES genes and subunits.

VertebrateSpeciesGene CEL RefSeq ID Prediction1,2GenBank IDChromosome locationExons (strand)Gene size (bps)UNIPROT IDAmino acidsSubunit MWpINo. of repeats

HumanHomo Sapiens CELNM_001807BC0425109:134, 927, 202-134, 936, 96911 (+ve)9,768P1983575679,6675.117
GorillaGorilla gorillaCELsc465912³sc65914:90, 194-97, 985³7,791Q9N1D1998 101,0264.539
RhesusMacaca mulattaCELchr15.6.020²³15:5, 562, 165-5, 571, 66211 (−ve)9,498³731 78,3024.815
MouseMus musculusCELNM_009885BC0068722:28, 411, 584-28, 418, 88211 (−ve)7,543Q64285598 65,6665.93
RatRattus norvegicusCELNM_016997M158933:7, 541, 329-7, 549, 22811 (−ve)7,900P07882612 67,0525.34
Guinea pigCavia porcellusCELsc427.013.12³sc274:846, 072-851, 86811 (−ve)5,797³598 65,1745.43
CowBos taurusCELNP_001013601BC14953011:106, 810, 242-106, 819, 10111 (+ve)8,762P30122599 65,5985.23
HorseEquus caballusCELchr25.415.1²³25:35, 342, 417-35, 350, 33011 (+ve)7,914³599 65,3105.33
DogCanis familiarisCELchr9.55.011²³9:54, 678, 403-54, 686, 29411 (−ve)7,892³709 75,9205.413
OpossumMonodelphis domesticaCELchr1.10.178²³1:460, 155, 249-460, 171, 51311 (+ve)16,265³579 63,5536.41
PlatypusOrnithorhynchus anatinusCELENSOANT23206²³Ultra814:471, 532-485, 25411 (+ve)13,723³557 61,6727.10
ChickenGallus gallusCELNP_001013015¹BX95047817:7, 428, 231-7, 433, 49011 (+ve)5,260³556 61,1916.60
LizardAnolis carolinensisCELENSACAT4924²³3534:801, 542-811, 60411 (+ve)10,063³553 61,4386.10
FrogXenopus tropicalisCELNP_001120027¹³1914:155, 996-171, 45411 (−ve)15,459³55260,6536.20
ZebrafishDanio rerioCEL1NM_199607BC07952921:4, 281, 250-4, 291, 23311 (−ve)9,984³55060,5216.00
ZebrafishDanio rerioCEL2AAH65887BC09689321:4, 298, 674-4, 307, 81011 (−ve)9,137³55060,4256.10
SticklebackGasterosteus aculeatusCELENSGACT24004²³XIV:11, 357, 393-11, 361, 60211 (−ve)4,210³55560,9635.70
MedakaOryzias latipesCELENSORLT18090²³12:26, 977, 209-26, 983, 64211 (+ve)6,434³55260,3295.80
FuguTakifugu rubripesCELENSTRUG2423²³sc3704:307, 466, 106-307, 469, 08711 (−ve)2,982³55461,4986.70
PufferfishTetraodon nigroviridisCELCAF94246CR654166Un5:12, 727, 719-12, 730, 51911 (−ve)4,210³55560,8595.70
CES
HumanHomo Sapiens CES1NM_001025195L0776516:54, 394, 465-54, 424, 46814 (−ve)30,004P2314156762,5216.2³
MouseMus musculusCES1aNM_001013764BC0893718:95, 544, 116-95, 572, 09114 (−ve)27,979Q5FWH456361,7445.1³
HumanHomo Sapiens CES2NM_003869BC03209516:65, 527, 040-65, 535, 42612 (+ve)8,387O0074855961,8075.7³
MouseMus musculusCes2aNM_133960BC0244918:107, 257, 972-107, 265, 31312 (+ve)7,342Q8QZR355861,9405.7³
HumanHomo Sapiens CES3NM_024922BC05367016:65, 552, 712-65, 564, 45013 (+ve)11,739Q9H6X757162,2825.4³
MouseMus musculusCes3aNM_198672AK1389328:107, 572, 572-107, 582, 00013 (+ve)21,512Q63880 55461,5105.8³
HumanHomo Sapiens CES4ANM_173815BC16663816:65, 580, 177-65, 600, 54314 (+ve)20,367Q5XG92 56160,3669.4³
MouseMus musculusCes4aNM_146213BC0263748:107, 655, 852-107, 673, 41714 (+ve)17,566³56362,1238.8³
HumanHomo Sapiens CES5ANM_001143685BC03907316:54, 437, 867-54, 466, 63413 (−ve)27,768Q6NT32 57563,9366.0³
MouseMus musculusCes5aNM_001003951AB1863938:96, 038, 095-96, 059, 60713 (+ve)21,512Q8R0W5 57564,1675.5³
NematodeCaenorhabditis elegansT28C12NM_072212AAB66159V:6, 323, 188-6, 326, 3739 (+ve)3,186Q4LDP0 65874,7369.2³

RefSeq refers to the NCBI reference sequence; ¹predicted NCBI sequence; ²predicted UCSC Genome Browser sequence; ³not available; 4gene scaffold ID; 5unidentified chromosome; pI refers to isoelectric point; bps refers to base pairs of nucleotide sequence; repeats number refers to the number of VNTR sequences at the CEL C-terminus.