About this Journal Submit a Manuscript Table of Contents
Cholesterol
Volume 2011 (2011), Article ID 851750, 7 pages
http://dx.doi.org/10.1155/2011/851750
Research Article

Dietary, Anthropometric, and Biochemical Determinants of Plasma High-Density Lipoprotein-Cholesterol in Free-Living Adults

1Department of Public Health, CeMENutri—Centre for Physical and Nutritional Metabolism, Sao Paulo State University (UNESP), District of Rubião Junior s/no, 18618-970 Botucatu, SP, Brazil
2Department of Pathology, Sao Paulo State University (UNESP), District of Rubião Junior s/no, 18618-900 Botucatu, SP, Brazil
3Department of Statistics, Sao Paulo State University (UNESP), District of Rubião Junior s/no, 18618-900 Botucatu, SP, Brazil

Received 31 August 2010; Revised 9 October 2010; Accepted 15 November 2010

Academic Editor: Dmitri Sviridov

Copyright © 2011 Erick Prado de Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The level of high-density lipoprotein is thought to be critical in inhibiting lesion formation as well as reducing the lipid load of preexisting atherosclerotic lesions. With the aim of determining the main determinants of plasma HDL-cholesterol (HDL-c) in free-living adults, 997 individuals (52.3 ± 10 years, 67% females) were selected for a descriptive cross-sectional study. The used data corresponded to the baseline obtained from participants clinically selected for a lifestyle modification program. Covariables of clinical, anthropometry, food intake, aerobic fitness, and plasma biochemistry were analyzed against plasma HDL-c either as continuous or categorized variables. After adjustments for age, gender, and BMI the excess of abdominal fat along with high carbohydrate-energy intake and altered plasma triglycerides were the stronger predictors of reduced plasma HDL-c. In conclusion lifestyle interventions aiming to normalize abdominal fatness and plasma triglycerides are recommended to restore normal levels of HDL-c in these free-living adults.