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Cholesterol
Volume 2011 (2011), Article ID 896360, 9 pages
http://dx.doi.org/10.1155/2011/896360
Research Article

APOE and FABP2 Polymorphisms and History of Myocardial Infarction, Stroke, Diabetes, and Gallbladder Disease

1Karmanos Cancer Institute, School of Medicine, Wayne State University, 4100 John R. Street, Detroit, MI 48201, USA
2Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
3Department of Obstetrics and Gynecology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
4Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
5Department of Family Medicine and Public Health Sciences, School of Medicine, Wayne State University, Detroit, MI 48201, USA

Received 24 February 2011; Revised 11 May 2011; Accepted 20 June 2011

Academic Editor: Bruce Griffin

Copyright © 2011 Ikuko Kato et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dysfunctional lipid metabolism plays a central role in pathogenesis of major chronic diseases, and genetic factors are important determinants of individual lipid profiles. We analyzed the associations of two well-established functional polymorphisms (FABP2 A54T and APOE isoforms) with past and family histories of 1492 population samples. FABP2-T54 allele was associated with an increased risk of past history of myocardial infarction (odds ratio (OR) = 1.51). Likewise, the subjects with APOE4, compared with E2 and E3, had a significantly increased risk of past history myocardial infarction (OR = 1.89). The OR associated with APOE4 was specifically increased in women for past history of myocardial infarction but decreased for gallstone disease. Interactions between gender and APOE isoforms were also significant or marginally significant for these two conditions. FABP2-T54 allele may be a potential genetic marker for myocardial infarction, and APOE4 may exert sex-dependent effects on myocardial infarction and gallbladder disease.