APOE and FABP2 Polymorphisms and History of Myocardial Infarction, Stroke, Diabetes, and Gallbladder Disease
Table 2
Odds ratios (ORs) and 95% confidence intervals (CIs) for history of selected chronic diseases according to FABP2 genotypes.
Diseases
Genotype
Medical history
Own
Family
Both
Yes/No
OR
95% CI
Yes/No
OR
95% CI
Yes/No
OR
95% CI
Myocardial infarction
AA
51/777
1.00
—
358/470
1.00
—
27/801
1.00
—
AT
51/509
1.55
1.02–2.35
262/298
1.14
0.92–1.42
35/525
2.04
1.20–3.46
TT
8/96
1.33
0.60–2.98
43/61
0.94
0.62–1.43
4/100
1.30
0.44–3.87
AT + TT
59/605
1.51
1.01–2.27
305/359
1.11
0.90–1.36
39/625
1.93
1.15–3.23
Stroke
AA
41/787
1.00
—
258/570
1.00
—
13/815
1.00
—
AT
30/530
1.11
0.67–1.84
158/402
0.86
0.68–1.09
8/552
—
—
TT
3/101
0.65
0.19–2.20
28/76
0.85
0.54–1.36
0/104
—
—
AT + TT
33/631
1.05
0.64–1.70
186/478
0.86
0.68–1.08
8/656
0.80
0.32–1.97
Diabetes
AA
118/710
1.00
—
298/530
1.00
—
75/753
1.00
—
AT
76/484
0.94
0.68–1.31
234/326
1.32
1.06–1.65
44/516
0.88
0.59–1.32
TT
10/94
0.66
0.32–1.35
41/63
1.26
0.82–1.93
4/100
0.46
0.16–1.30
AT + TT
86/578
0.90
0.66–1.24
275/389
1.31
1.06–1.63
48/616
0.82
0.55–1.21
Gallbladder disease
AA
112/716
1.00
—
148/680
1.00
—
30/798
1.00
—
AT
81/479
1.05
0.76–1.44
118/442
1.20
0.91–1.59
21/539
0.93
0.52–1.68
TT
10/94
0.74
0.37–1.49
14/90
0.73
0.40–1.33
2/102
0.56
0.13–2.43
AT + TT
91/573
1.00
0.73–1.36
132/532
1.13
0.86–1.47
23/641
0.88
0.50–1.56
ORs were adjusted for age, sex, race, educational levels, cigarette smoking (pack-years), alcohol intake, body mass index, energy-adjusted dietary saturated fat, cholesterol, fiber and total calcium intakes, and family size. P values for a linear trend for the number of T-alleles.
