Table 3: Odds ratios (ORs) and 95% confidence intervals (CIs) for history of selected chronic diseases according to APOE genotypes.

DiseasesGenotypeMedical history
OwnFamilyBoth
Yes/NoOR95% CIYes/NoOR95% CIYes/NoOR95% CI

Myocardial infarctionE216/2231.140.62–2.08113/1261.160.86–1.559/2300.990.46–2.13
E351/8101.00378/4831.0033/8281.00
E443/3491.951.25–3.04172/2201.010.79–1.2924/3681.640.94–2.86
E4 versus E2E3 1.891.24–2.880.980.77–1.241.640.97–2.80
𝑃 = 0 . 0 2 2 𝑃 = 0 . 4 7 7 𝑃 = 0 . 1 1 9

StrokeE215/2241.280.67–2.4577/1621.110.81–1.523/2360.750.20–2.74
E337/8241.00255/6061.0012/8491.00
E422/3701.100.63–1.93112/2800.940.72–1.236/3860.870.31–2.42
E4 versus E2E3 1.030.61–1.760.920.71–1.190.930.35–2.49
𝑃 = 0 . 7 6 4 𝑃 = 0 . 3 8 2 𝑃 = 0 . 9 0 4

DiabetesE236/2030.980.64–1.5198/1411.090.81–1.4726/2131.350.81–2.23
E3121/7401.00323/5381.0064/7971.00
E447/3450.730.50–1.07152/2401.000.78–1.2833/3591.020.64–1.61
E4 versus E2E3 0.730.51–1.060.980.77–1.250.940.61–1.46
𝑃 = 0 . 1 7 3 𝑃 = 0 . 6 4 5 𝑃 = 0 . 3 9 5

Gallbladder diseaseE236/2031.090.72–1.6749/1901.200.83–1.7411/2281.380.66–2.90
E3121/7401.00157/7041.0029/8321.00
E446/3460.800.55–1.1774/3181.120.81–1.5313/3790.980.50–1.95
E4 versus E2E3 0.790.55–1.131.070.79–1.450.910.47–1.75
𝑃 = 0 . 1 8 7 𝑃 = 0 . 8 6 6 𝑃 = 0 . 4 7 3

ORs were adjusted for age, sex, race, educational levels, cigarette smoking (pack-years), alcohol intake, body mass index, energy-adjusted dietary saturated fat, cholesterol, fiber and total calcium intakes, and family size, E2 includes E2/E2, E2/E3, and E2/E4, and E4 includes E4/E3, and E4/E4. P values for a linear trend for E2, E3 and E4.