APOE and FABP2 Polymorphisms and History of Myocardial Infarction, Stroke, Diabetes, and Gallbladder Disease
Table 3
Odds ratios (ORs) and 95% confidence intervals (CIs) for history of selected chronic diseases according to APOE genotypes.
Diseases
Genotype
Medical history
Own
Family
Both
Yes/No
OR
95% CI
Yes/No
OR
95% CI
Yes/No
OR
95% CI
Myocardial infarction
E2
16/223
1.14
0.62–2.08
113/126
1.16
0.86–1.55
9/230
0.99
0.46–2.13
E3
51/810
1.00
—
378/483
1.00
—
33/828
1.00
—
E4
43/349
1.95
1.25–3.04
172/220
1.01
0.79–1.29
24/368
1.64
0.94–2.86
E4 versus E2E3
1.89
1.24–2.88
0.98
0.77–1.24
1.64
0.97–2.80
Stroke
E2
15/224
1.28
0.67–2.45
77/162
1.11
0.81–1.52
3/236
0.75
0.20–2.74
E3
37/824
1.00
—
255/606
1.00
—
12/849
1.00
—
E4
22/370
1.10
0.63–1.93
112/280
0.94
0.72–1.23
6/386
0.87
0.31–2.42
E4 versus E2E3
1.03
0.61–1.76
0.92
0.71–1.19
0.93
0.35–2.49
Diabetes
E2
36/203
0.98
0.64–1.51
98/141
1.09
0.81–1.47
26/213
1.35
0.81–2.23
E3
121/740
1.00
—
323/538
1.00
—
64/797
1.00
—
E4
47/345
0.73
0.50–1.07
152/240
1.00
0.78–1.28
33/359
1.02
0.64–1.61
E4 versus E2E3
0.73
0.51–1.06
0.98
0.77–1.25
0.94
0.61–1.46
Gallbladder disease
E2
36/203
1.09
0.72–1.67
49/190
1.20
0.83–1.74
11/228
1.38
0.66–2.90
E3
121/740
1.00
—
157/704
1.00
—
29/832
1.00
—
E4
46/346
0.80
0.55–1.17
74/318
1.12
0.81–1.53
13/379
0.98
0.50–1.95
E4 versus E2E3
0.79
0.55–1.13
1.07
0.79–1.45
0.91
0.47–1.75
ORs were adjusted for age, sex, race, educational levels, cigarette smoking (pack-years), alcohol intake, body mass index, energy-adjusted dietary saturated fat, cholesterol, fiber and total calcium intakes, and family size, E2 includes E2/E2, E2/E3, and E2/E4, and E4 includes E4/E3, and E4/E4. P values for a linear trend for E2, E3 and E4.
