Table 4: Odds ratios (ORs) and 95% confidence intervals (CIs) for past history of selected chronic diseases according APOE genotypes and gender.

Diseases GenotypeFemalesMalesP values for interaction
Yes/NoOR95% CIYes/NoOR95% CI

Myocardial infarctionE24/1290.520.17–1.6212/941.700.81–3.56
E322/4751.0029/3351.00
E421/2051.931.00–3.7022/1441.921.03–3.58
E4 versus E2E3 2.181.16–4.091.680.94–3.00
𝑃 = 0 . 0 0 9 𝑃 = 0 . 4 6 3 0.008

StrokeE29/1241.340.57–3.156/1001.220.42–3.55
E321/4761.0016/3481.00
E413/2131.110.53–2.339/1571.050.42–2.61
E4 versus E2E3 1.030.51–2.061.000.42–2.38
𝑃 = 0 . 7 7 2 𝑃 = 0 . 8 4 6 0.850

DiabetesE222/1110.990.56–1.7314/920.930.47–1.87
E368/4291.0053/3111.00
E432/1940.890.55–1.4415/1510.500.26–0.97
E4 versus E2E3 0.890.56–1.420.510.27–0.97
𝑃 = 0 . 7 0 6 𝑃 = 0 . 1 0 3 0.762

Gallbladder diseaseE231/1021.280.79–2.085/1010.580.22–1.58
E392/4051.0029/3351.00
E431/1950.670.43–1.0615/1511.140.58–2.26
E4 versus E2E3 0.640.41–0.991.270.66–2.46
𝑃 = 0 . 0 2 5 𝑃 = 0 . 2 4 4 0.088

ORs were adjusted for age, race, educational levels, cigarette smoking (pack-years), alcohol intake, body mass index, energy-adjusted dietary saturated fat, cholesterol, fiber and total calcium intakes, and family size. E2 includes E2/E2, E2/E3, and E2/E4, and E4 includes E4/E3 and E4/E4. P values for a linear trend for E2, E3 and E4.