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Cholesterol
Volume 2012 (2012), Article ID 536396, 6 pages
http://dx.doi.org/10.1155/2012/536396
Research Article

Modulation of Lipoprotein Cholesterol Levels in Plasmodium berghei Malarial Infection by Crude Aqueous Extract of Ganoderma lucidum

1Department of Biochemistry, College of Natural Science, Joseph Ayo Babalola University, Ikeji-Arakeji, Osun, Nigeria
2Department of Biochemistry, Faculty of Science, Adekunle Ajasin University, Akungba Akoko, Ondo , Nigeria
3Department of Medical Biochemistry, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria
4Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin, Nigeria

Received 5 April 2012; Revised 12 June 2012; Accepted 18 June 2012

Academic Editor: Gerhard M. Kostner

Copyright © 2012 Olarewaju M. Oluba et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In this study, attempt is made to establish changes in serum and liver lipoprotein cholesterols accompanying Plasmodium berghei malarial infection in mice treated with aqueous extract of Ganoderma lucidum at 100, 250, and 500 mg/kg body weight in comparison with 15 mg/kg chloroquine (CQ). Significant increases in all the lipoprotein fractions were observed in infected untreated mice compared with normal control mice. Treatment with 100 and 250 mg/kg G. lucidum extract produced significant reduction in serum total cholesterol (TC) and low-density cholesterol (LDL-C) contents compared with 500 mg/kg G. lucidum and CQ. Treatment with CQ, however, produced significant reduction in hepatic TC and LDL-C compared with the extract. A dose-dependent significant increase in serum high-density lipoprotein cholesterol (HDL-C) was observed in the G. lucidum treated mice compared with normal control but significantly lower compared with CQ-treated mice. Liver HDL-C level was significantly higher in CQ-treated mice compared with normal control and significantly lower compared with G. lucidum-treated and infected untreated mice. A dose-dependent effect of the extract was observed in both serum and liver very-low density lipoprotein cholesterol (VLDL-C). The implication of these results is discussed with respect to the parasite survival and proliferation in the serum and liver.