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Figure 4: Effect of combined simvastatin and ezetimibe treatments on cholesterol levels in HCD-fed zebrafish larvae. Zebrafish larvae were fed a HCD for 14 days. Simvastatin and ezetimibe were administered as described in legends to Figures 1 and 2. Total cholesterol was measured in lipid extracts from larvae homogenates. Values of total cholesterol per larva were normalized to the values in the group that received HCD only (second column). Homogenates of 20–40 animals were pooled together for each data point in each individual experiment.