Table 1: MicroRNAs involved in cholesterol metabolism.

miRNA
Target tissue/cell type
Target genes
Biological functionReferences

miR-122
Primary mouse hepatocytesALDOA
CS
Glucose homeostasis
Krebs cycle
[22, 23]

miR-33a and
miR-33b
Liver and
macrophage
ABCA1;
ABCG1; NPC1
CROT;
HADHB; CPT1; SIRT6; PRKAA1
IRS2
Cellular cholesterol efflux
Fatty acid oxidation
Insulin signaling
[12, 24, 25]

miR-758
Human and mouse macrophages and hepatic cell line
ABCA1Cellular cholesterol efflux [13]
Human neuroglioma cell lineSLC38a1; NTM; EPHA7Aminoacid synthesis, neurite outgrowing, and neuronal migration

miR-106bMouse neuroblastoma cell line and human hepatocyteABCA1Cellular cholesterol efflux and Aβ production[14]