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Cholesterol
Volume 2012 (2012), Article ID 861924, 7 pages
http://dx.doi.org/10.1155/2012/861924
Clinical Study

Use of Lipid-Lowering Medications and the Likelihood of Achieving Optimal LDL-Cholesterol Goals in Coronary Artery Disease Patients

1Cardiology Consultants of Philadelphia, Philadelphia, PA 19107, USA
2Division of Cardiology, Drexel University College of Medicine, Philadelphia, PA 19107, USA
3Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PA 19107, USA

Received 17 April 2012; Revised 10 June 2012; Accepted 12 June 2012

Academic Editor: Jan Wouter Jukema

Copyright © 2012 Dean G. Karalis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. L. Roger, A. S. Go, D. M. Lloyd-Jones, et al., “Heart disease and stroke statistics—2011 update: a report from the American Heart Association,” Circulation, vol. 123, pp. e18–e209, 2011. View at Publisher · View at Google Scholar
  2. S. C. Smith Jr., E. J. Benjamin, R. O. Bonow, et al., “AHA/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease: 2011 update: a guideline from the American Heart Association and American College of Cardiology Foundation,” Circulation, vol. 124, pp. 2458–2473, 2011.
  3. Heart Protection Study Collaborative Group, “MRC/BHF heart protection study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial,” The Lancet, vol. 360, no. 9326, pp. 7–22, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. C. P. Cannon, E. Braunwald, C. H. McCabe et al., “Intensive versus moderate lipid lowering with statins after acute coronary syndromes,” The New England Journal of Medicine, vol. 350, no. 15, pp. 1495–1504, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. J. C. LaRosa, S. M. Grundy, D. D. Waters et al., “Intensive lipid lowering with atorvastatin in patients with stable coronary disease,” The New England Journal of Medicine, vol. 352, no. 14, pp. 1425–1435, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. T. R. Pedersen, O. Faergeman, J. J. P. Kastelein et al., “High-dose atorvastatin versus usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial,” Journal of the American Medical Association, vol. 294, no. 19, pp. 2437–2445, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group, “Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12, 064 survivors of myocardial infarction: a double-blind randomized trial,” The Lancet, vol. 376, pp. 1658–1669, 2010.
  8. Cholesterol Treatment Trialists’ (CTT) Collaboration, “Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomized trials,” The Lancet, vol. 376, pp. 1670–1681, 2010.
  9. J. Hsia, J. G. MacFadyen, J. Monyak, and P. M. Ridker, “Cardiovascular event reduction and adverse events among subjects attaining low-density lipoprotein cholesterol <50 mg/dl with rosuvastatin: the JUPITER trial (justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin),” Journal of the American College of Cardiology, vol. 57, no. 16, pp. 1666–1675, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. S. M. Grundy, J. I. Cleeman, N. B. Merz et al., “Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines,” Circulation, vol. 110, no. 2, pp. 227–239, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Mosca, E. J. Benjamin, K. Berra, et al., “Effectiveness-based guidelines for the prevention of cardiovascular disease in women-2011 update: a guideline from the American heart association,” Circulation, vol. 123, pp. 1243–1262. View at Publisher · View at Google Scholar
  12. J. D. Brunzell, M. Davidson, C. D. Furberg et al., “Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation,” Diabetes Care, vol. 31, no. 4, pp. 811–822, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. A. L. Catapano, J. Chapman, O. Wiklund, and M. R. Taskinen, “The new joint EAS/ESC guidelines for the management of dyslipidaemias,” Atherosclerosis, vol. 217, no. 1, p. 1, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. D. G. Karalis, R. D. Subramanya, S. E. Hessen, L. Liu, and M. F. Victor, “Achieving optimal lipid goals in patients with coronary artery disease,” American Journal of Cardiology, vol. 107, no. 6, pp. 886–890, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Ghandehari, S. Kamal-Bahl, and N. D. Wong, “Prevalence and extent of dyslipidemia and recommended lipid levels in US adults with and without cardiovascular comorbidities: the National Health and Nutrition Examination Survey 2003-2004,” American Heart Journal, vol. 156, no. 1, pp. 112–119, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. M. H. Davidson, K. C. Maki, T. A. Pearson et al., “Results of the National Cholesterol Education (NCEP) program evaluation project utilizing novel T-technology (NEPTUNE) II survey and implications for treatment under the recent NCEP writing group recommendations,” American Journal of Cardiology, vol. 96, no. 4, pp. 556–563, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. D. D. Waters, C. Brotons, C. W. Chiang et al., “Lipid treatment assessment project 2: a multinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol goals,” Circulation, vol. 120, no. 1, pp. 28–34, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. L. T. Meade, “Barriers to achieving LDL cholesterol goals,” U.S. Pharmacist, vol. 32, no. 3, pp. 66–71, 2007. View at Scopus
  19. A. B. Kauffman, K. L. Olson, M. L. Youngblood, E. B. Zadvorny, T. Delate, and J. A. Merenich, “Attainment of low-density lipoprotein cholesterol goals in coronary artery disease,” Journal of Clinical Lipidology, vol. 4, no. 3, pp. 173–180, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. L. Mosca, N. B. Merz, R. S. Blumenthal et al., “Opportunity for intervention to achieve American Heart Association guidelines for optimal lipid levels in high-risk women in a managed care setting,” Circulation, vol. 111, no. 4, pp. 488–493, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. A. G. Kennedy, C. D. MacLean, B. Littenberg, P. A. Ades, and R. G. Pinckney, “The challenge of achieving national cholesterol in patients with diabetes,” Diabetes Care, vol. 28, no. 5, pp. 1029–1034, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. T. A. Stacy and A. Egger, “Results of retrospective chart review to determine improvement in lipid goal attainment in patients treated by high-volume prescribers of lipid-modifying drugs,” Journal of Managed Care Pharmacy, vol. 12, no. 9, pp. 745–751, 2006. View at Scopus
  23. A. T. Yan, R. T. Yan, M. Tan et al., “Contemporary management of dyslipidemia in high-risk patients: targets still not met,” American Journal of Medicine, vol. 119, no. 8, pp. 676–683, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. L. Laforest, P. Moulin, T. Souchet et al., “Correlates of LDL-cholesterol goal attainment in patients under lipid lowering therapy,” Atherosclerosis, vol. 199, no. 2, pp. 368–377, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. E. Stein, S. Stender, P. Mata et al., “Achieving lipoprotein goals in patients at high risk with severe hypercholesterolemia: efficacy and safety of ezetimibe co-administered with atorvastatin,” American Heart Journal, vol. 148, no. 3, pp. 447–455, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. M. H. Davidson, T. McGarry, R. Bettis et al., “Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia,” Journal of the American College of Cardiology, vol. 40, no. 12, pp. 2125–2134, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. H. S. Friedman, S. Rajagopalan, J. P. Barnes, and H. Roseman, “Combination therapy with Ezetimibe/Simvastatin versus Statin Monotherapy for low-density lipoprotein cholesterol reduction and goal attainment in a real-world clinical setting,” Clinical Therapeutics, vol. 33, no. 2, pp. 212–224, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. The SHARP Investigators, “The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (study of Heart and Renal Protection): a randomized placebo-controlled trial,” The Lancet, vol. 377, pp. 2181–2192, 2011.
  29. A. J. Taylor, T. C. Villines, E. J. Stanek et al., “Extended-release niacin or ezetimibe and carotid intima-media thickness,” The New England Journal of Medicine, vol. 361, no. 22, pp. 2113–2122, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. C. M. Ballantyne, M. H. Davidson, J. McKenney, L. H. Keller, D. R. Bajorunas, and R. H. Karas, “Comparison of the safety and efficacy of a combination tablet of niacin extended release and Simvastatin versus Simvastatin monotherapy in patients with increased Non-HDL cholesterol (from the SEACOAST I study),” American Journal of Cardiology, vol. 101, no. 10, pp. 1428–1436, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. The AIM-HIGH Investigators, “Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy,” The New England Journal of Medicine, vol. 365, pp. 2255–2267, 2011.
  32. G. A. Nichols and C. E. Koro, “Does statin therapy initiation increase the risk for myopathy? An observational study of 32,225 diabetic and nondiabetic patients,” Clinical Therapeutics, vol. 29, no. 8, pp. 1761–1770, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. J. M. Foody, S. G. Sajjan, X. H. Hu et al., “Loss of early gains in low-density lipoprotein cholesterol goal attainment among high-risk patients,” Journal of Clinical Lipidology, vol. 4, no. 2, pp. 126–132, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. The ACCORD Study Group, “Effects of combination lipid therapy in type 2 diabetes mellitus,” The New England Journal of Medicine, vol. 362, pp. 1563–1574, 2010.
  35. B. V. Howard, M. J. Roman, R. B. Devereux et al., “Effect of lower targets for blood pressure and LDL cholesterol on atherosclerosis in diabetes: the SANDS randomized trial,” Journal of the American Medical Association, vol. 299, no. 14, pp. 1678–1689, 2008. View at Publisher · View at Google Scholar · View at Scopus