Review Article
Lipoprotein(a): Cellular Effects and Molecular Mechanisms
Table 1
Lp(a) subunits responsible for cellular effects.
| Process | LDL-apoB-100 | Apo(a) | Region | References |
| Thrombosis | | | | | (i) Platelet aggregation | | | | [11–17] | (ii) tissue factor pathway | — | | | [19–21] | (iii) plasminogen activation | — | | KIV type 10, KV | [8, 20, 23–28] | (iv) TGF activation | × | | KIV type 9 | [34–37] | (v) TGF production | — | | KIV type 10, KV | [37] | Inflammation | | | | | (i) Oxidised phospholipids | × | | KV | [44–46] | (ii) monocyte migration | | | | [19, 51, 53] | (iii) monocyte adhesion | × | | KIV type 10 | [19] | Vascular remodelling | | | | | (i) SMC proliferation | | | KIV type 9 | [35, 36, 58, 62] | (ii) SMC migration | — | | KIV type 9 | [36] | (iii) EC proliferation | | | KIV type 10, KV | [37, 64, 65] | (iv) EC migration | | | KIV type 10, KV | [37, 65] | (v) EC contraction | — | | KIV type 10 | [70] |
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For detailed information, see main body of text and highlighted references. Key: = positive for effect, × = negative for effect, — = not tested.
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