About this Journal Submit a Manuscript Table of Contents
Cholesterol
Volume 2013 (2013), Article ID 289481, 5 pages
http://dx.doi.org/10.1155/2013/289481
Research Article

APOA2 Polymorphism in Relation to Obesity and Lipid Metabolism

1Medical Research Division, Biological Anthropology Department, National Research Centre, Cairo 12622, Egypt
2Human Genetics and Genome Research Division, Medical Molecular Genetics Department, National Research Centre, Cairo 12622, Egypt

Received 15 September 2013; Accepted 21 October 2013

Academic Editor: Francisco Blanco-Vaca

Copyright © 2013 Moushira Erfan Zaki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. This study aims to analysis the relationship between c.-492T>C polymorphism in APOA2 gene and the risk for obesity in a sample of Egyptian adolescents and investigates its effect on body fat distribution and lipid metabolism. Material and Methods. A descriptive, cross-sectional study was conducted on 303 adolescents. They were 196 obese and 107 nonobese, aged 16–19 years old. Variables examined included body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), systolic and diastolic blood pressure (BP), body fat percentage (BF%), abdominal visceral fat layer, and dietary intake. Abdominal visceral fat thickness was determined by ultrasonography. The polymorphism in the APOA2 c.-492T>C was analyzed by PCR amplification. Results. Genotype frequencies were in Hardy-Weinberg equilibrium. The frequency of the mutant C allele was significantly higher in obese cases compared to nonobese. After multivariate adjustment, waist, BF% and visceral adipose layer, food consumption, and HDL-C were significantly higher in homozygous allele CC carriers than TT+TC carriers. Conclusions. Homozygous individuals for the C allele had higher obesity risk than carriers of the T allele and had elevated levels of visceral adipose tissue and serum HDL-C. Moreover, the study shows association between the APOA2 c.-492T>C polymorphism and food consumption.