Short-Term Effect of Pitavastatin Treatment on Glucose and Lipid Metabolism and Oxidative Stress in Fasting and Postprandial State Using a Test Meal in Japanese Men
Table 1
Fasting metabolic parameters at 0 and 4 weeks after pitavastatin.
0 Weeks
4 Weeks
P
Body mass index (kg/m2)
23.4 (21.3–29.2)
23.7 (21.7–29.4)
0.557
Total cholesterol (mg/dL)
0.0001
Low-density lipoprotein cholesterol (mg/dL)
<0.0001
High-density lipoprotein cholesterol (mg/dL)
0.8321
Triglycerides (mg/dL)
98.5 (78.0–138.8)
89.5 (63.0–132.8)
0.287
Remnant-like particle cholesterol (mg/dL)
0.1239
FFA (mEq/L)
0.8926
Apolipoprotein AI (mg/dL)
0.3207
Apolipoprotein B (mg/dL)
0.0004
Apolipoprotein E (mg/dL)
0.0735
Arachidonic acid (g/mL)
0.0485
Eicosapentaenoic acid (μg/mL)
0.3319
Docosahexaenoic acid (μg/mL)
0.6055
Glucose (mg/dL)
0.4502
Insulin (μU/mL)
5.9 (4.9–16.3)
5.9 (2.8–15.7)
0.028
HOMA-R
1.28 (1.12–3.80)
1.26 (0.56–3.47)
0.322
High sensitivity CRP (mg/L)
0.187
Urinary 8OHdG (ng/mgCr)
0.1882
Urinary isoprostane (ng/mgCr)
0.4423
Urinary isoprostane production rate (ng/kg/hour)
0.4894
Serum creatinine (mg/dL)
0.8143
eGFR (mL/min/1.73 m2)
0.5168
Albumin/creatinine ratio (mg/gCr)
0.4383
(mL/minute)
0.0431
Serum uric acid (mg/dL)
0.4786
(mL/minute)
0.0072
/ (%)
0.0409
Uric acid excretion (mg/gCr)
0.2385
Adjusted urinary excretion of uric acid (mg/kg/hour)
0.0378
Values are shown as mean ± standard deviation. BMI, triglycerides, insulin, and HOMA-R are shown as median and interquartile range. HOMA-R: homeostasis model assessment ratio; 8OHdG: 8-Hydroxydeoxyguanosine; eGFR: estimated glomerular filtration rate; : creatinine clearance; : uric acid clearance.
