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Cholesterol
Volume 2013 (2013), Article ID 681475, 8 pages
http://dx.doi.org/10.1155/2013/681475
Clinical Study

HDL-C Response Variability to Niacin ER in US Adults

1GlaxoSmithKline, Clinical Effectiveness & Safety, 5 Moore Drive, B.3116, Durham, NC 27709-3398, USA
2GlaxoSmithKline, Heart Failure DPU, Medicines Discovery and Development, King of Prussia, PA 19406, USA
3GlaxoSmithKline, Worldwide Epidemiology, Durham, NC 27709, USA
4Exponent Health Sciences, Bellevue, WA 98004, USA

Received 20 December 2012; Accepted 28 January 2013

Academic Editor: Francisco Blanco-Vaca

Copyright © 2013 Jennifer B. Christian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Niacin is the most effective treatment currently available for raising HDL-C levels. Objective. To evaluate if gender and baseline lipid levels have an effect on the HDL-C response of niacin ER and to identify factors that predict response to niacin ER at the 500 mg dose. Material and Methods. The change in HDL-C effect between baseline and follow-up levels was quantified in absolute change as well as dichotomized into high versus low response (high response was defined as an HDL-C effect of >15% increase and low response was HDL-C <5%) in a sample of 834 individuals. Results. Both males and females with low HDL-C levels at baseline exhibited a response to treatment in the multivariate model (males, HDL-C <40 mg/dL: , 95% CI: 2.36–11.39; females, HDL-C <50 mg/dL: , 95% CI: 1.84–15.79). There was also a significant difference in the mean HDL-C effect between baseline and follow-up HDL-C levels in the 500 mg niacin ER dose group for both males (mean HDL-C effect = 0.08, ) and females (mean HDL-C effect = 0.10, ). Conclusion. Baseline HDL-C levels are the biggest predictor of response to niacin ER treatment for both males and females among the factors evaluated.