Table 2: Overall HDL effect by niacin ER dose.

Demographics and lipids500 mg niacin ER dose1000 mg niacin ER dose valueb
Baseline HDL-C levels
Mean (SD)
Follow-up
HDL-C levels
Mean (SD)
HDL-C effect
Mean (SD)
valuea Baseline HDL-C levels
Mean (SD)
Follow-up
HDL-C levels
Mean (SD)
HDL-C effect
Mean (SD)
valuea

Gender
 Males48037.1 (0.4)39.4 (0.4)0.08 (0.01)<0.00112039.0 (0.9)41.6 (0.9)0.08 (0.02)0.0290.768b
 Females20045.5 (1.1)49.3 (1.2)0.10 (0.01)0.0193448.5 (2.6)57.4 (3.6)0.19 (0.03)0.0480.021b
valuec <0.001<0.0010.2210.001<0.0010.0090.053d
Age (years)
 18 to 407937.9 (1.2)40.0 (1.1)0.10 (0.04)0.1961238.9 (2.9)40.4 (1.7)0.07 (0.05)0.6590.660b
 41 to 6551639.4 (0.5)42.2 (0.6)0.08 (0.01)<0.00113141.3 (1.1)45.8 (1.3)0.12 (0.02)0.0080.057b
 ≥668542.5 (1.4)45.5 (1.4)0.08 (0.02)0.1261141.2 (2.2)41.9 (1.8)0.03 (0.05)0.8030.335b
valued0.0320.0180.8420.7990.3430.2420.613d
HDL-C mg/dL (both genders)
 4042332.8 (0.3)36.3 (0.4)0.12 (0.01)<0.0018733.5 (0.5)37.7 (0.8)0.13 (0.02)<0.0010.437b
 ≥4025750.8 (0.7)52.3 (0.8)0.03 (0.01)0.1686750.9 (1.2)54.7 (1.9)0.07 (0.02)0.0960.094b
valuec<0.001<0.001<0.001<0.001<0.0010.0370d
LDL-C mg/dL
 <13026439.0 (0.7)41.3 (0.8)0.07 (0.01)0.0258840.6 (1.1)44.9 (1.2)0.12 (0.02)0.0080.160b
 ≥13017641.8 (0.9)44.6 (1.0)0.08 (0.02)0.0313344.7 (2.7)48.9 (3.5)0.09 (0.03)0.3440.802b
valuec0.0110.0060.4740.1610.2910.4890.472d
TG mg/dL
 <15019244.0 (1.1)46.5 (1.1)0.08 (0.02)0.1026046.6 (1.6)50.4 (2.2)0.08 (0.02)0.1660.899b
 ≥15048338.0 (0.4)40.9 (0.5)0.08 (0.01)<0.0019337.6 (1.0)41.8 (1.1)0.12 (0.02)0.0050.060b
valuec<0.001<0.0010.943<0.0010.0010.1110.362d
TC mg/dL
 <20030136.8 (0.6)39.5 (0.6)0.09 (0.01)0.0019639.6 (1.0)43.7 (1.2)0.11 (0.02)0.0070.362b
 ≥20037542.2 (0.6)44.9 (0.7)0.08 (0.01)0.0045743.7 (1.9)47.6 (2.4)0.10 (0.03)0.2000.530b
valuec<0.001<0.0010.2590.0520.1440.5490.195d

Definition of lipids: HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TG: triglycerides; TC: total cholesterol.
a value tested the null hypothesis that there is no difference in the baseline and follow-up HDL-C levels using the Student’s -test.
b value tested the null hypotheses that there is no difference in the mean HDL-C effect across niacin ER dose groups using the Student’s -test.
c value tested the null hypothesis that there is no difference in the mean HDL-C effect across each risk factor/lipid level category using the Student’s -test.
d value tested the null hypothesis that there is no difference in the mean HDL-C effect across each risk factor/lipid level category using the -statistic.