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Cholesterol
Volume 2013 (2013), Article ID 769457, 9 pages
http://dx.doi.org/10.1155/2013/769457
Research Article

Cholesterol Metabolism and Weight Reduction in Subjects with Mild Obstructive Sleep Apnoea: A Randomised, Controlled Study

1Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, P.O. BOX 1627, 70211 Kuopio, Finland
2Institute of Clinical Medicine, Department of Otorhinolaryngology, Kuopio University Hospital, and University of Eastern Finland, P.O. BOX 1777, 70211 Kuopio, Finland
3Oivauni Sleep Clinic, Puijonkatu 12 b, 70100 Kuopio, Finland
4Institute of Clinical Medicine, Department of Medicine, Division of Clinical Nutrition, Kuopio University Hospital, P.O. BOX 1777, 70211 Kuopio, Finland
5Institute of Clinical Medicine, Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, and University of Eastern Finland, P.O. BOX 1777, 70211 Kuopio, Finland
6Institute of Clinical Medicine, Respiratory Medicine, Kuopio University Hospital, and University of Eastern Finland, P.O. BOX 1777, 70211 Kuopio, Finland
7Division of Internal Medicine, Department of Medicine, University of Helsinki, Helsinki, P.O. BOX 700, 00029 HUS, Finland

Received 12 March 2013; Accepted 29 April 2013

Academic Editor: Francisco Blanco-Vaca

Copyright © 2013 Maarit Hallikainen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To evaluate whether parameters of obstructive sleep apnoea (OSA) associate with cholesterol metabolism before and after weight reduction, 42 middle-aged overweight subjects with mild OSA were randomised to intensive lifestyle intervention ( ) or to control group ( ) with routine lifestyle counselling only. Cholesterol metabolism was evaluated with serum noncholesterol sterol ratios to cholesterol, surrogate markers of cholesterol absorption (cholestanol and plant sterols) and synthesis (cholestenol, desmosterol, and lathosterol) at baseline and after 1-year intervention. At baseline, arterial oxygen saturation ( ) was associated with serum campesterol ( ) and inversely with desmosterol ratios ( ) independently of gender, BMI, and homeostasis model assessment index of insulin resistance (HOMA-IR). Apnoea-hypopnoea index (AHI) was not associated with cholesterol metabolism. Weight reduction significantly increased and serum cholestanol and decreased AHI and serum cholestenol ratios. In the groups combined, the changes in AHI were inversely associated with changes of cholestanol and positively with cholestenol ratios independent of gender and the changes of BMI and HOMA-IR ( ). In conclusion, mild OSA seemed to be associated with cholesterol metabolism independent of BMI and HOMA-IR. Weight reduction increased the markers of cholesterol absorption and decreased those of cholesterol synthesis in the overweight subjects with mild OSA.