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Volume 2013 (2013), Article ID 769457, 9 pages
Cholesterol Metabolism and Weight Reduction in Subjects with Mild Obstructive Sleep Apnoea: A Randomised, Controlled Study
1Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, P.O. BOX 1627, 70211 Kuopio, Finland
2Institute of Clinical Medicine, Department of Otorhinolaryngology, Kuopio University Hospital, and University of Eastern Finland, P.O. BOX 1777, 70211 Kuopio, Finland
3Oivauni Sleep Clinic, Puijonkatu 12 b, 70100 Kuopio, Finland
4Institute of Clinical Medicine, Department of Medicine, Division of Clinical Nutrition, Kuopio University Hospital, P.O. BOX 1777, 70211 Kuopio, Finland
5Institute of Clinical Medicine, Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, and University of Eastern Finland, P.O. BOX 1777, 70211 Kuopio, Finland
6Institute of Clinical Medicine, Respiratory Medicine, Kuopio University Hospital, and University of Eastern Finland, P.O. BOX 1777, 70211 Kuopio, Finland
7Division of Internal Medicine, Department of Medicine, University of Helsinki, Helsinki, P.O. BOX 700, 00029 HUS, Finland
Received 12 March 2013; Accepted 29 April 2013
Academic Editor: Francisco Blanco-Vaca
Copyright © 2013 Maarit Hallikainen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- T. Young, P. E. Peppard, and D. J. Gottlieb, “Epidemiology of obstructive sleep apnea: a population health perspective,” American Journal of Respiratory and Critical Care Medicine, vol. 165, no. 9, pp. 1217–1239, 2002.
- S. R. Coughlin, L. Mawdsley, J. A. Mugarza, P. M. A. Calverley, and J. P. H. Wilding, “Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome,” European Heart Journal, vol. 25, no. 9, pp. 735–741, 2004.
- F. J. Nieto, T. B. Young, B. K. Lind et al., “Association of sleep-disordered breathing sleep apnea, and hypertension in a large community-based study,” Journal of the American Medical Association, vol. 283, no. 14, pp. 1829–1836, 2000.
- P. E. Peppard, T. Young, M. Palta, and J. Skatrud, “Prospective study of the association between sleep-disordered breathing and hypertension,” The New England Journal of Medicine, vol. 342, no. 19, pp. 1378–1384, 2000.
- E. Shahar, C. W. Whitney, S. Redline et al., “Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the sleep heart health study,” American Journal of Respiratory and Critical Care Medicine, vol. 163, no. 1, pp. 19–25, 2001.
- A. S. M. Shamsuzzaman, B. J. Gersh, and V. K. Somers, “Obstructive sleep apnea: implications for cardiac and vascular disease,” Journal of the American Medical Association, vol. 290, no. 14, pp. 1906–1914, 2003.
- H. Tuomilehto, M. Peltonen, M. Partinen et al., “Sleep-disordered breathing is related to an increased risk for type 2 diabetes in middle-aged men, but not in women -the FIN-D2D survey,” Diabetes, Obesity and Metabolism, vol. 10, no. 6, pp. 468–475, 2008.
- N. M. Punjabi, B. S. Caffo, J. L. Goodwin et al., “Sleep-disordered breathing and mortality: A Prospective Cohort Study,” PLoS Medicine, vol. 6, no. 8, article e1000132, 2009.
- M. Partinen and C. Guilleminault, “Daytime sleepiness and vascular morbidity at seven-year follow-up in obstructive sleep apnea patients,” Chest, vol. 97, no. 1, pp. 27–32, 1990.
- J. Sahlman, K. Miettinen, K. Peuhkurinen et al., “The activation of the inflammatory cytokines in overweight patients with mild obstructive sleep apnoea: sleep apnea and inflammation,” Journal of Sleep Research, vol. 19, no. 2, pp. 341–348, 2010.
- A. B. Newman, F. J. Nieto, U. Guidry et al., “Relation of sleep-disordered breathing to cardiovascular disease risk factors: The Sleep Heart Health Study,” American Journal of Epidemiology, vol. 154, no. 1, pp. 50–59, 2001.
- F. Roche, E. Sforza, V. Pichot et al., “Obstructive sleep apnoea/hypopnea influences high-density lipoprotein cholesterol in the elderly,” Sleep Medicine, vol. 10, no. 8, pp. 882–886, 2009.
- C. Tsioufis, K. Thomopoulos, K. Dimitriadis et al., “The incremental effect of obstructive sleep apnoea syndrome on arterial stiffness in newly diagnosed essential hypertensive subjects,” Journal of Hypertension, vol. 25, no. 1, pp. 141–146, 2007.
- L. F. Drager, L. A. Bortolotto, M. C. Lorenzi, A. C. Figueiredo, E. M. Krieger, and G. Lorenzi-Filho, “Early signs of atherosclerosis in obstructive sleep apnea,” American Journal of Respiratory and Critical Care Medicine, vol. 172, no. 5, pp. 613–618, 2005.
- L. F. Drager, V. Y. Polotsky, and G. Lorenzi-Filho, “Obstructive sleep apnea: an emerging risk factor for atherosclerosis,” Chest, vol. 140, no. 2, pp. 534–542, 2011.
- T. Young, J. Skatrud, and P. E. Peppard, “Risk factors for obstructive sleep apnea in adults,” Journal of the American Medical Association, vol. 291, no. 16, pp. 2013–2016, 2004.
- T. A. Miettinen and H. Gylling, “Cholesterol absorption efficiency and sterol metabolism in obesity,” Atherosclerosis, vol. 153, no. 1, pp. 241–248, 2000.
- H. Gylling, M. Hallikainen, M. Kolehmainen et al., “Cholesterol synthesis prevails over absorption in metabolic syndrome,” Translational Research, vol. 149, no. 6, pp. 310–316, 2007.
- G. Pillar and N. Shehadeh, “Abdominal fat and sleep apnea: the chicken or the egg?” Diabetes Care, vol. 31, pp. S303–S309, 2008.
- H. P. I. Tuomilehto, J. M. Seppä, M. M. Partinen et al., “Lifestyle intervention with weight reduction: first-line treatment in mild obstructive sleep apnea,” American Journal of Respiratory and Critical Care Medicine, vol. 179, no. 4, pp. 320–327, 2009.
- P. Simonen, H. Gylling, and T. A. Miettinen, “Acute effects of weight reduction on cholesterol metabolism in obese type 2 diabetes,” Clinica Chimica Acta, vol. 316, no. 1-2, pp. 55–61, 2002.
- P. Simonen, H. Gylling, A. N. Howard, and T. A. Miettinen, “Introducing a new component of the metabolic syndrome: low cholesterol absorption,” American Journal of Clinical Nutrition, vol. 72, no. 1, pp. 82–88, 2000.
- T. A. Miettinen, R. S. Tilvis, and Y. A. Kesäniemi, “Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population,” American Journal of Epidemiology, vol. 131, no. 1, pp. 20–31, 1990.
- W. W. Flemons, D. Buysse, S. Redline et al., “Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research,” Sleep, vol. 22, no. 5, pp. 667–689, 1999.
- D. R. Matthews, J. P. Hosker, and A. S. Rudenski, “Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man,” Diabetologia, vol. 28, no. 7, pp. 412–419, 1985.
- T. A. Miettinen, “Cholesterol metabolism during ketoconazole treatment in man,” Journal of Lipid Research, vol. 29, no. 1, pp. 43–51, 1988.
- C. L. Phillips, B. J. Yee, N. S. Marshall, P. Y. Liu, D. R. Sullivan, and R. R. Grunstein, “Continuous positive airway pressure reduces postprandial lipidemia in obstructive sleep apnea: a randomized, placebo-controlled crossover trial,” American Journal of Respitatory and Critical Care Medicine, vol. 184, no. 3, pp. 355–361, 2011.
- G. V. Robinson, J. C. T. Pepperell, H. C. Segal, R. J. O. Davies, and J. R. Stradling, “Circulating cardiovascular risk factors in obstructive sleep apnoea: data from randomised controlled trials,” Thorax, vol. 59, no. 9, pp. 777–782, 2004.
- J. E. Shaw, N. M. Punjabi, J. P. Wilding, K. G. M. M. Alberti, and P. Z. Zimmet, “Sleep-disordered breathing and type 2 diabetes. A report from the International Diabetes Federation Taskforce on Epidemiology and Prevention,” Diabetes Research and Clinical Practice, vol. 81, no. 1, pp. 2–12, 2008.
- A. M. Dattilo and P. M. Kris-Etherton, “Effects of weight reduction on blood lipids and lipoproteins: a meta- analysis,” American Journal of Clinical Nutrition, vol. 56, no. 2, pp. 320–328, 1992.
- J. Li, V. Savransky, A. Nanayakkara, P. L. Smith, C. P. O'Donnell, and V. Y. Polotsky, “Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia,” Journal of Applied Physiology, vol. 102, no. 2, pp. 557–563, 2007.
- J. Li, L. N. Thorne, N. M. Punjabi et al., “Intermittent hypoxia induces hyperlipidemia in lean mice,” Circulation Research, vol. 97, no. 7, pp. 698–706, 2005.
- V. Savransky, J. Jun, J. Li et al., “Dyslipidemia and atherosclerosis induced by chronic intermittent hypoxia are attenuated by deficiency of stearoyl coenzyme a desaturase,” Circulation Research, vol. 103, no. 10, pp. 1173–1180, 2008.
- L. F. Drager, J. Li, M. K. Shin, et al., “Intermittent hypoxia inhibits clearance of triglyceride-rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnoea,” European Heart Journal, vol. 19, no. 11, pp. 2167–2174, 2011.
- J. Pihlajamäki, H. Gylling, T. A. Miettinen, and M. Laakso, “Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men,” Journal of Lipid Research, vol. 45, no. 3, pp. 507–512, 2004.
- P. P. Simonen, H. K. Gylling, and T. A. Miettinen, “Diabetes contributes to cholesterol metabolism regardless of obesity,” Diabetes Care, vol. 25, no. 9, pp. 1511–1515, 2002.
- T. A. Miettinen, H. Gylling, T. Strandberg, and S. Sarna, “Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian simvastatin survival study,” British Medical Journal, vol. 316, no. 7138, pp. 1127–1130, 1998.
- E. Ballester, J. R. Badia, L. Hernández et al., “Evidence of the effectiveness of continuous positive airway pressure in the treatment of sleep apnea/hypopnea syndrome,” American Journal of Respiratory and Critical Care Medicine, vol. 159, no. 2, pp. 495–501, 1999.
- K. Johansson, E. Hemmingsson, R. Harlid et al., “Longer term effects of very low energy diet on obstructive sleep apnoea in cohort derived from randomised controlled trial: Prospective Observational Follow-up Study,” British Medical Journal, vol. 342, no. d3017, 2011.