Table 1: There are several transcription factors and pathways that regulate PON1 expression.

Some important PON1 regulator factors Modulator signal

High glucose level Protein kinase C (PKC)
High insulin level Protein kinase C (PKC)
Zeta (PKC ζ)
Statinsp44/p42 MAP
FibratesSREBP-2, PPARα
RosiglitazonePPARγ
Aspirin (salicylate) AhR
Dietary polyphenols AhR
QuercetinSREPB-2
PomegranatePKA, PPAR-γ
β-Carotene p-AMPK
Cholesterol lowering alkaloid
(benzyl tetrahydroquinoline)
JNK
EplerenoneAldosterone
Bile acids FXR, FGFR4
Urokinase-type plasminogen activator (uPA) PPARγ
LPS and inflammatory cytokinesPPARδ
Testosterone?
Estrogen and methoxyprogesterone acetate
Erythropoietin beta
Ethanol
 Light drinkers
 Heavy drinkers