Cholesterol Levels in Genetically Determined Familial Hypercholesterolaemia in Russian Karelia
Table 1
Clinical and biochemical features of patients with heterozygous FH.
Possible FH () Group 1
Probable FH () Group 2
Definite FH () Group 3
Post hoc analyses
Age (years)
50.84 ± 1.57
53.00 ± 3.30
51.56 ± 1.49
>0.05
Male (%)
31.7
42.3
45.9
1-3 < 0.05
BMI (kg/m2)
26.93 ± 0.86
28.81 ± 1.79
28.07 ± 0.59
>0.05
Smoking (%)
21.3 ± 4.1
22.2 ± 4.2
24.4 ± 4.3
>0.05
Arterial hypertension (%)
61.4 ± 4.1
65.4 ± 3.8
69.5 ± 4.6
>0.05
Ischemic heart disease (%)
26.8 ± 4.4
50.0 ± 9.6
58.6 ± 4.9
p1-3 < 0.05, p1-2 < 0.05, p2-3 > 0.05
Myocardial infarction (%)
18.5 ± 3.9
26.9 ± 8.5
30.0 ± 4.6
p1-3 = 0.007 p1-2 = 0.04
DLCN (points)
3.92 ± 0.08
6.08 ± 0.05
11.40 ± 0.48
p1-3, p2-3, p1-2 < 0.05
TC (mmol/L)
8.71 ± 0.09
9.15 ± 0.17
10.14 ± 0.17
p1-3 < 0.05, p2-3 < 0.05, p1-2 = 0.26
LDL-C (mmol/L)
5.81 ± 0.08
6.58 ± 0.17
7.52 ± 0.15
p1-2, p1-3, p2-3 < 0.05
TG (mmol/L)
1.90 ± 0.10
1.96 ± 0.17
1.74 ± 0.08
HDL-C (mmol/L)
1.57 ± 0.05
1.41 ± 0.08
1.49 ± 0.04
LDL-C: low density lipoprotein cholesterol (average rate). FH: familial hypercholesterolemia. TC: total cholesterol (average rate). HDL-C: high density lipoprotein cholesterol (average rate). TG: triglycerides (average rate). DLCN: Dutch Lipid Clinic Network. BMI: body mass index (average rate). -: value of pairwise difference between Group and Group . The level of significance was .
