|
Compound | Dietary source | Chemotherapy drug | Effect | Biological system | Reference |
|
Influence on treatment efficacy |
|
Ginsenosides | | Cisplatin | Enhancement of drug-induced antiproliferative effect | Human breast carcinoma MCF-7 cells | [63, 64] |
|
Ginseng | 5-Fluorouracil | Increase in antiproliferative effect | Human colorectal cancer HCT-116 cells | [63, 65] |
Curcumin | Turmeric | Vinorelbine | Enhancement of chemotherapeutic efficacy | Human squamous cell lung carcinoma H520 cells | [66, 67] |
Catechins/theanine | Green tea | Doxorubicin | Enhancement of antitumour activity | Ehrlich ascites carcinoma and M5076 ovarian sarcoma tumour-bearing mice | [9, 68–70] |
Quercetin | | | Increase in reduction of tumour growth | Mice bearing human tumour xenografts | [71] |
| |
Cisplatin | Potentiation of cytotoxic effect | Human ovarian and endometrial cancer cell lines | [71] |
|
Many foods such as onions, apples, berries, and tea | Doxorubicin | Potentiation of growth-inhibitory activity | Doxorubicin-resistant human breast tumour MCF-7 cells | [68, 71, 72] |
| | Busulfan | Synergistic antiproliferative activity | Human leukaemia K562 cells | [71, 73] |
Genistein | | Cisplatin | Increased cytotoxic effect | Cisplatin-sensitive and cisplatin-resistant human 2008 ovarian carcinoma cells | [9, 71] |
| | | Attenuation of inhibitory effect of tamoxifen on tumour cell growth | Oestrogen-dependent human breast cancer MCF-7 cells | [9, 74] |
|
Soy foods | Tamoxifen | Attenuation of tamoxifen effect on reducing of tumour burden | Female Sprague-Dawley rats with induced mammary tumours | [75] |
| | | Synergistic growth inhibition | Oestrogen receptor-negative human breast carcinoma MDA-MB-435 cells | [9, 76] |
Daidzein | Soy foods | Tamoxifen | Improvement of drug activity to reduce tumour burden | Female Sprague-Dawley rats with induced mammary tumours | [9, 75] |
Tangeretin | Tangerine and other citrus peels | Tamoxifen | Complete blocking of growth inhibitory effect of tamoxifen | Female nude mice inoculated with human MCF-7/6 mammary adenocarcinoma cells | [9, 68, 77] |
|
Influence on side effects of chemotherapy |
|
Ginsenosides | | Cyclophosphamide | Protection against drug-induced genotoxicity and apoptosis in bone marrow cells and peripheral lymphocytes | Mouse peripheral lymphocytes and bone marrow cells | [78, 79] |
|
Ginseng | Cisplatin | Attenuation of drug-induced nausea and vomiting | Rat model | [63, 80] |
Quercetin | Many foods such as onions, apples, berries, and tea | Cisplatin | Protection of normal renal tubular cells from drug toxicity | Pig kidney tubular epithelial LLC-PK1 cells | [71, 81] |
|
Influence on drug resistance |
|
Ginsenosides | Ginseng | Paclitaxel | Chemosensitisation | Multidrug-resistant breast cancer cells | [63, 82] |
Catechins/theanine | | Doxorubicin | Inhibition of drug efflux from tumour cells | Drug-resistant M5076 ovarian sarcoma tumour-bearing mice | [9, 68, 70] |
|
Green tea | Daunorubicin | Increase in drug accumulation in tumour cells | Multidrug-resistant P-gp overexpressing human epidermal carcinoma KB-C2 cells | [20, 83] |
| | Irinotecan, SN-38 | Inhibiting drug transport into biliary elimination and prolonging half-lives in plasma | Male Sprague-Dawley rats | [20, 84] |
|
Quercetin | | Vincristine | Increase in drug uptake in tumour cells | Doxorubicin-resistant human myelogenous leukaemia K562 cells | [20, 85] |
| | Tamoxifen | Enhancement of drug bioavailability decreasing the efflux by MDR transporters | Female Sprague-Dawley rats | [20, 86] |
| | Paclitaxel | Enhancement of drug bioavailability | Male Sprague-Dawley rats | [20, 87] |
|
Many foods such as onions, apples, berries, and tea | Doxorubicin | Potentiation of antitumour effect reducing P-gp expression | Multidrug-resistant human breast cancer MCF-7 cells | [9, 20, 72] |
| | Topotecan | Chemosensitisation | Mouse fibrosarcoma WEHI-S cells | [71, 88] |
| | Gemcitabine | Chemosensitisation | Mouse fibrosarcoma WEHI-S cells | [71, 88] |
Genistein | Soy foods | Paclitaxel | Enhancement in systemic exposure of drug | Male Sprague-Dawley rats | [20, 89] |
|