Modeling Spike-Train Processing in the Cerebellum Granular Layer and Changes in Plasticity Reveal Single Neuron Effects in Neural Ensembles

Figure 2

Firing patterns observed with AdEx model. (A) and (B) shows the in vitro behavior receiving 1 spike through the MF synapses. In vivo behavior (burst-burst transmission) is simulated (C) and (D) via bursts through the MF synapses. (A) and (C) show traces with no inhibition while (B) and (D) show traces with inhibition. Responses from left to right indicate input activation patterns from 4 MF excitations to 1 MF excitation. The AdEx model faithfully reproduced granule cell spiking behavior in vitro and in vivo [9, 19, 28].