Modeling Spike-Train Processing in the Cerebellum Granular Layer and Changes in Plasticity Reveal Single Neuron Effects in Neural Ensembles
Figure 5
Effect of inhibition on variation in number of spikes and spiking cells. With varying inhibition, the number of spiking cells and total number of spikes varied. With 1 spike via MF as input ((a), in vitro behaviour), the total number of spiking cells varied from 200–600 cells and 1-2 spikes modulated by the inhibitory inputs (-axis). Tactile stimulation induced two types of bursts in vivo [33]. (b) shows the number of spiking cells in vivo (as short burst of 5 spikes at 500 Hz via MF) with respect to changes in number of spikes as inhibitory inputs (-axis) were changed. Variation in the number of spiking cells and number of spikes is shown. With a longer burst (9 spikes at 500 Hz via MF) in vivo (c), there were more spikes and inhibition did not cause a sharp change in number of spikes or spiking cells in the network (see also Table 5). The number of active cells can be observed also by looking at the increase of the number of “silent” cells. The granule cells favour a better role as signal-to-noise enhancers in the network [44] and facilitate burst-burst transmission.
