Modeling Spike-Train Processing in the Cerebellum Granular Layer and Changes in Plasticity Reveal Single Neuron Effects in Neural Ensembles
Figure 7
“Spot” activation and evoked LFP with selective NMDA dysfunction. Population code via evoked LFP in vitro response was reconstructed. Control (a) shows the clear reproducibility of and waves [18]. NR2A/NR2B knockouts show selective dysfunction of NMDA receptors. 1% (b), 5% (c), and 10% (d) cells with NMDA receptor blocked do not show much difference in population code although intracellular spiking remains altered (not shown). A small decrease in peak amplitudes was noticed. The robustness of the population code during spiking in granule cells adds to the sparse recoding theory [4] and clearly granule neurons favour their role as signal-to-noise enhancers for sensory and tactile information received via the mossy fibers (MFs).
