- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Computational Intelligence and Neuroscience
Volume 2012 (2012), Article ID 575129, 8 pages
Analyzing the Effects of Gap Junction Blockade on Neural Synchrony via a Motoneuron Network Computational Model
1Department of Computer Science, Stony Brook University, Stony Brook, NY 11794-4440, USA
2Department of Physiology & Biophysics, Stony Brook University, Stony Brook, NY 11794-8661, USA
3Program in Neuroscience, SUNY, Stony Brook University, Stony Brook, NY 11794-5230, USA
Received 20 April 2012; Revised 11 October 2012; Accepted 22 October 2012
Academic Editor: Karim Oweiss
Copyright © 2012 Heraldo Memelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- B. Pfeuty, G. Mato, D. Golomb, and D. Hansel, “Electrical synapses and synchrony: the role of intrinsic currents,” The Journal of Neuroscience, vol. 23, no. 15, pp. 6280–6294, 2003.
- M. V. L. Bennett and R. S. Zukin, “Electrical coupling and neuronal synchronization in the mammalian brain,” Neuron, vol. 41, no. 4, pp. 495–511, 2004.
- M. V. L. Bennett and D. A. Goodenough, “Gap junctions, electrotonic coupling, and intercellular communication,” Neurosciences Research Program Bulletin, vol. 16, no. 3, pp. 373–486, 1978.
- R. Bruzzone, “Mini-review: connexins, gap junctions and cell-cell signalling in the nervous system,” European The Journal of Neuroscience, vol. 9, no. 1, pp. 1–6, 1997.
- P. E. Micevych and L. Abelson, “Distribution of mRNAs coding for liver and heart gap junction proteins in the rat central nervous system,” The Journal of Comparative Neurology, vol. 305, no. 1, pp. 96–118, 1991.
- R. Dermietzel and D. C. Spray, “Gap junctions in the brain: where, what type, how many and why?” Trends in Neurosciences, vol. 16, no. 5, pp. 186–192, 1993.
- B. Nadarajah, A. M. Jones, W. H. Evans, and J. G. Parnavelas, “Differential expression of connexins during neocortical development and neuronal circuit formation,” The Journal of Neuroscience, vol. 17, no. 9, pp. 3096–3111, 1997.
- D. F. Condorelli, R. Parenti, F. Spinella et al., “Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons,” European The Journal of Neuroscience, vol. 10, no. 3, pp. 1202–1208, 1998.
- N. Belluardo, G. Mudò, A. Trovato-Salinaro et al., “Expression of Connexin36 in the adult and developing rat brain,” Brain Research, vol. 865, no. 1, pp. 121–138, 2000.
- D. F. Condorelli, N. Belluardo, A. Trovato-Salinaro, and G. Mudò, “Expression of Cx36 in mammalian neurons,” Brain Research Reviews, vol. 32, no. 1, pp. 72–85, 2000.
- R. Parenti, M. Gulisano, A. Zappala', and F. Cicirata, “Expression of connexin36 mRNA in adult rodent brain,” NeuroReport, vol. 11, no. 7, pp. 1497–1502, 2000.
- I. C. Solomon, T. J. Halat, M. R. El, and M. H. O'Neal, “Localization of connexin26 and connexin32 in putative CO2-chemosensitive brainstem regions in rat,” Respiration Physiology, vol. 129, no. 1-2, pp. 101–121, 2001.
- S. C. Massey, J. J. O'Brien, E. B. Trexler et al., “Multiple neuronal connexins in the mammalian retina,” Cell Communication and Adhesion, vol. 10, no. 4–6, pp. 425–430, 2003.
- I. C. Solomon, “Connexin36 distribution in putative CO2-chemosensitive brainstem regions in rat,” Respiratory Physiology & Neurobiology, vol. 139, no. 1, pp. 1–20, 2003.
- L. P. De Sevilla Müller, K. Dedek, U. Janssen-Bienhold et al., “Expression and modulation of connexin 30.2, a novel gap junction protein in the mouse retina,” Visual Neuroscience, vol. 27, no. 3-4, pp. 91–101, 2010.
- V. Alvarez-Maubecin, F. García-Hernández, J. T. Williams, and E. J. Van Bockstaele, “Functional coupling between neurons and glia,” The Journal of Neuroscience, vol. 20, no. 11, pp. 4091–4098, 2000.
- I. C. Solomon, T. J. Halat, R. El-Maghrabi, and M. H. O'Neal III, “Differential expression of connexin26 and connexin32 in the pre-Bötzinger complex of neonatal and adult rat,” The Journal of Comparative Neurology, vol. 440, no. 1, pp. 12–19, 2001.
- D. Cardone and T. Halat, “Expression of gap junction proteins in cranial (hypoglossal) and spinal (phrenic) respiratory motor nuclei in rat,” The FASEB Journal, vol. 16, article A810, 2002.
- J. B. Dean, D. Ballantyne, D. L. Cardone, J. S. Erlichman, and I. C. Solomon, “Role of gap junctions in CO2 chemoreception and respiratory control,” American Journal of Physiology, vol. 283, no. 4, pp. L665–L670, 2002.
- I. C. Solomon and J. B. Dean, “Gap junctions in CO2-chemoreception and respiratory control,” Respiratory Physiology & Neurobiology, vol. 131, no. 3, pp. 155–173, 2002.
- J. B. Dean, R. Q. Huang, J. S. Erlichman, T. L. Southard, and D. T. Hellard, “Cell-cell coupling occurs in dorsal medullary neurons after minimizing anatomical-coupling artifacts,” Neuroscience, vol. 80, no. 1, pp. 21–40, 1997.
- R. Q. Huang, J. S. Erlichman, and J. B. Dean, “Cell-cell coupling between CO2-excited neurons in the dorsal medulla oblongata,” Neuroscience, vol. 80, no. 1, pp. 41–57, 1997.
- J. C. Rekling, G. D. Funk, D. A. Bayliss, X. W. Dong, and J. L. Feldman, “Synaptic control of motoneuronal excitability,” Physiological Reviews, vol. 80, no. 2, pp. 767–852, 2000.
- C. Bou-Flores and A. J. Berger, “Gap junctions and inhibitory synapses modulate inspiratory motoneuron synchronization,” Journal of Neurophysiology, vol. 85, no. 4, pp. 1543–1551, 2001.
- I. C. Solomon, K. H. Chon, and M. N. Rodriguez, “Blockade of brain stem gap junctions increases phrenic burst frequency and reduces phrenic burst synchronization in adult rat,” Journal of Neurophysiology, vol. 89, no. 1, pp. 135–149, 2003.
- A. Sherman and J. Rinzel, “Model for synchronization of pancreatic β-cells by gap junction coupling,” Biophysical Journal, vol. 59, no. 3, pp. 547–559, 1991.
- R. E. Winmill and M. S. Hedrick, “Gap junction blockade with carbenoxolone differentially affects fictive breathing in larval and adult bullfrogs,” Respiratory Physiology & Neurobiology, vol. 138, no. 2-3, pp. 239–251, 2003.
- J. L. Perez Velazquez and P. L. Carlen, “Gap junctions, synchrony and seizures,” Trends in Neurosciences, vol. 23, no. 2, pp. 68–74, 2000.
- J. D. Hunter, “Matplotlib: a 2D graphics environment,” Computing in Science & Engineering, vol. 9, no. 3, Article ID 4160265, pp. 90–95, 2007.
- L. K. Purvis and R. J. Butera, “Ionic current model of a hypoglossal motoneuron,” Journal of Neurophysiology, vol. 93, no. 2, pp. 723–733, 2005.
- D. Hansel, G. Mato, C. Meunier, and L. Neltner, “On numerical simulations of integrate-and-fire neural networks,” Neural Computation, vol. 10, no. 2, pp. 467–483, 1998.
- R. Rozental, M. Srinivas, and D. C. Spray, “How to close a gap junction channel. Efficacies and potencies of uncoupling agents,” Methods in Molecular Biology, vol. 154, pp. 447–476, 2001.
- W. J. Larsen, “Biological implications of gap junction structure, distribution and composition: a review,” Tissue and Cell, vol. 15, no. 5, pp. 645–671, 1983.
- A. Sherman and J. Rinzel, “Rhythmogenic effects of weak electrotonic coupling in neuronal models,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 6, pp. 2471–2474, 1992.
- K. T. Moortgat, T. H. Bullock, and T. J. Sejnowski, “Gap junction effects on precision and frequency of a model pacemaker network,” Journal of Neurophysiology, vol. 83, no. 2, pp. 984–997, 2000.
- G. R. Juszczak and A. H. Swiergiel, “Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: animal and human studies,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 33, no. 2, pp. 181–198, 2009.
- B. W. Connors, “Tales of a dirty drug: carbenoxolone, gap junctions, and seizures,” Epilepsy Currents, vol. 12, no. 2, pp. 66–68, 2012.
- C. S. Peskin, Mathematical Aspects of Heart Physiology, Courant Institute of Mathematical Sciences, New York University, 1975.
- P. Östborn, B. Wohlfart, and G. Ohlén, “Arrhythmia as a result of poor intercellular coupling in the sinus node: a simulation study,” Journal of Theoretical Biology, vol. 211, no. 3, pp. 201–217, 2001.
- P. Pakhotin and A. Verkhratsky, “Electrical synapses between Bergmann glial cells and Purkinje neurones in rat cerebellar slices,” Molecular and Cellular Neuroscience, vol. 28, no. 1, pp. 79–84, 2005.
- R. Vogel and R. Weingart, “The electrophysiology of gap junctions and gap junction channels and their mathematical modelling,” Biology of the Cell, vol. 94, no. 7-8, pp. 501–510, 2002.