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Computational Intelligence and Neuroscience
Volume 2013 (2013), Article ID 949816, 19 pages
Enhanced Synaptic Connectivity in the Dentate Gyrus during Epileptiform Activity: Network Simulation
1Laboratório de Neurociência Experimental e Computacional, Departamento de Engenharia de Biossistemas, Universidade Federal de São João del-Rei (UFSJ), Brazil
2Programa de Engenharia Biomédica, Universidade Federal do Rio de Janeiro (UFRJ/COPPE), Brazil
3Disciplina de Neurologia Experimental, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Brazil
4Disciplina de Neurofisiologia e Fisiologia do Exercício, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Brazil
Received 7 August 2012; Revised 6 December 2012; Accepted 20 December 2012
Academic Editor: Steven Bressler
Copyright © 2013 Keite Lira de Almeida França et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- J. Engel, Seizures and Epilepsy, Edited by F. A. Davis Company, F. A. Davis Company, Philadelphia, Pa, USA, 1989.
- M. J. S. Fernandes, E. A. Cavalheiro, J. P. Leite, and D. S. Persike, “Temporal lobe epilepsy: cell death and molecular targets activity,” in Underlying Mechanisms of Epilepsy, F. S. Kaneez, Ed., pp. 117–134, InTech, Rijeka, Croatia, 2011.
- A. K. Sharma, R. Y. Reams, W. H. Jordan, M. A. Miller, H. L. Thacker, and P. W. Snyder, “Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions,” Toxicologic Pathology, vol. 35, no. 7, pp. 984–999, 2007.
- F. A. Guedes, O. Y. Galvis-Alonso, and J. P. Leite, “Plasticidade neuronal associada à epilepsia do lobo temporal mesial: insights a partir de Estudos em Humanos e em Modelos Animais,” Journal of Epilepsy and Clinical Neurophysiology, vol. 12, pp. 10–17, 2006.
- P. S. Buckmaster, G. F. Zhang, and R. Yamawaki, “Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit,” Journal of Neuroscience, vol. 22, no. 15, pp. 6650–6658, 2002.
- M. J. A. M. van Puttena, L. C. Liefaardb, M. Danhof, and R. A. Voskuyl, “Quantitative EEG analysis: a biomarker for epileptogenesis,” in Pharmacoresistance in Epilepsy-Modelling and Prediction of Disease Progression, C. Liefaard, Ed., pp. 51–67, 2008.
- K. Morimoto, M. Fahnestock, and R. J. Racine, “Kindling and status epilepticus models of epilepsy: rewiring the brain,” Progress in Neurobiology, vol. 73, no. 1, pp. 1–60, 2004.
- J. E. Franck, J. Pokorny, D. D. Kunkel, and P. A. Schwartzkroin, “Physiologic and morphologic characteristics of granule cell circuitry in human epileptic hippocampus,” Epilepsia, vol. 36, no. 6, pp. 543–558, 1995.
- M. M. Okazaki, P. Molnár, and J. V. Nadler, “Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth,” Journal of Neurophysiology, vol. 81, no. 4, pp. 1645–1660, 1999.
- J. P. Wuarin and F. E. Dudek, “Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rats,” Journal of Neuroscience, vol. 16, no. 14, pp. 4438–4448, 1996.
- W. W. Lytton, K. M. Hellman, and T. P. Sutula, “Computer models of hippocampal circuit changes of the kindling model of epilepsy,” Artificial Intelligence in Medicine, vol. 13, no. 1-2, pp. 81–97, 1998.
- V. Santhakumar, I. Aradi, and I. Soltesz, “Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography,” Journal of Neurophysiology, vol. 93, no. 1, pp. 437–453, 2005.
- R. J. Morgan and I. Soltesz, “Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 16, pp. 6179–6184, 2008.
- A. C. G. Almeida, A. M. Rodrigues, F. A. Scorza et al., “Mechanistic hypotheses for nonsynaptic epileptiform activity induction and its transition from the interictal to ictal state-Computational simulation,” Epilepsia, vol. 49, no. 11, pp. 1908–1924, 2008.
- W. S. McCulloch and W. Pitts, “A logical calculus of the ideas immanent in nervous activity,” The Bulletin of Mathematical Biophysics, vol. 5, no. 4, pp. 115–133, 1943.
- J. Dyhrfjeld-Johnsen, V. Santhakumar, R. J. Morgan, R. Huerta, L. Tsimring, and I. Soltesz, “Topological determinants of epileptogenesis in large-scale structural and functional models of the dentate gyrus derived from experimental data,” Journal of Neurophysiology, vol. 97, no. 2, pp. 1566–1587, 2007.
- J. R. Wolff and G. P. Wagner, “Selforganization in synaptogenesis: interaction between the formation of excitatory and inhibitory synapses,” in Synergetics of the Brain, E. Basar, H. Flohr, H. Haken, and A. J. Mandell, Eds., pp. 50–59, Springer, Berlin, Germany, 1983.
- I. E. Dammasch and G. P. Wagner, “On the properties of randomly connected McCulloch-Pitts networks: differences between input-constant and input-variant networks,” Cybernetics and Systems, vol. 15, no. 1-2, pp. 91–117, 1984.
- I. E. Dammasch, G. P. Wagner, and J. R. Wolff, “Self-stabilization of neuronal networks I. The compensation algorithm for synaptogenesis,” Biological Cybernetics, vol. 54, no. 4-5, pp. 211–222, 1986.
- M. Butz, K. Lehmann, I. E. Dammasch, and G. Teuchert-Noodt, “A theoretical network model to analyse neurogenesis and synaptogenesis in the dentate gyrus,” Neural Networks, vol. 19, no. 10, pp. 1490–1505, 2006.
- I. E. Dammasch, G. P. Wagner, and J. R. Wolff, “Self-stabilization of neuronal networks. II. Stability conditions for synaptogenesis,” Biological Cybernetics, vol. 58, no. 3, pp. 149–158, 1988.
- A. C. G. Almeida, A. M. Rodrigues, M. A. Duarte et al., “Biophysical aspects of the nonsynaptic epileptiform activity,” in Underlying Mechanisms of Epilepsy, F. S. Kaneez, Ed., pp. 189–218, InTech, Rijeka, Croatia, 2011.
- L. J. Cromme and I. E. Dammasch, “Compensation type algorithms for neural nets: stability and convergence,” Journal of Mathematical Biology, vol. 27, no. 3, pp. 327–340, 1989.
- J. Lisman, “A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory,” Proceedings of the National Academy of Sciences of the United States of America, vol. 86, no. 23, pp. 9574–9578, 1989.
- J. T. Trachtenberg, B. E. Chen, G. W. Knott et al., “Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex,” Nature, vol. 420, no. 6917, pp. 788–794, 2002.
- V. De Paola, A. Holtmaat, G. Knott et al., “Cell type-specific structural plasticity of axonal branches and boutons in the adult neocortex,” Neuron, vol. 49, no. 6, pp. 861–875, 2006.
- J. E. Cavazos, G. Golarai, and T. P. Sutula, “Mossy fiber synaptic reorganization induced by kindling: time course of development, progression, and permanence,” Journal of Neuroscience, vol. 11, no. 9, pp. 2795–2803, 1991.
- B. Adams, M. Lee, M. Fahnestock, and R. J. Racine, “Long-term potentiation trains induce mossy fiber sprouting,” Brain Research, vol. 775, no. 1-2, pp. 193–197, 1997.
- U. Sayin, S. Osting, J. Hagen, P. Rutecki, and T. Sutula, “Spontaneous seizures and loss of axo-axonic and axo-somatic inhibition induced by repeated brief seizures in kindled rats,” Journal of Neuroscience, vol. 23, no. 7, pp. 2759–2768, 2003.
- H. R. Pathak, F. Weissinger, M. Terunuma et al., “Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy,” Journal of Neuroscience, vol. 27, no. 51, pp. 14012–14022, 2007.
- S. W. Briggs and A. S. Galanopoulou, “Altered GABA signaling in early life epilepsies,” Neural Plasticity, vol. 2011, Article ID 527605, 16 pages, 2011.
- I. Cohen, V. Navarro, S. Clemenceau, M. Baulac, and R. Miles, “On the origin of interictal activity in human temporal lobe epilepsy in vitro,” Science, vol. 298, no. 5597, pp. 1418–1421, 2002.
- G. Huberfeld, L. Wittner, S. Clemenceau et al., “Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy,” Journal of Neuroscience, vol. 27, no. 37, pp. 9866–9873, 2007.
- A. T. U. Schaefers, K. Grafen, G. Teuchert-Noodt, and Y. Winter, “Synaptic remodeling in the dentate gyrus, CA3, CA1, subiculum, and entorhinal cortex of mice: effects of deprived rearing and voluntary running,” Neural Plasticity, vol. 2010, Article ID 870573, 11 pages, 2010.
- V. Santhakumar, R. Bender, M. Frotscher et al., “Granule cell hyperexcitability in the early post-traumatic rat dentate gyrus: the 'irritable mossy cell' hypothesis,” Journal of Physiology, vol. 524, no. 1, pp. 117–134, 2000.
- J. V. Nadler, “The recurrent mossy fiber pathway of the epileptic brain,” Neurochemical Research, vol. 28, no. 11, pp. 1649–1658, 2003.
- P. S. Buckmaster and F. H. Lew, “Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy,” Journal of Neuroscience, vol. 31, no. 6, pp. 2337–2347, 2011.
- J. G. R. Jefferys and H. L. Haas, “Synchronized bursting of CA1 hippocampal pyramidal cells in the absence of synaptic transmission,” Nature, vol. 300, no. 5891, pp. 448–450, 1982.
- C. P. Taylor and F. E. Dudek, “Synchronous neural afterdischarges in rat hippocampal slices without active chemical synapses,” Science, vol. 218, no. 4574, pp. 810–812, 1982.
- Z. Q. Xiong and J. L. Stringer, “Sodium pump activity, not glial spatial buffering, clears potassium after epileptiform activity induced in the dentate gyrus,” Journal of Neurophysiology, vol. 83, no. 3, pp. 1443–1451, 2000.
- M. Frotscher, P. Jonas, and R. S. Sloviter, “Synapses formed by normal and abnormal hippocampal mossy fibers,” Cell and Tissue Research, vol. 326, no. 2, pp. 361–367, 2006.
- W. W. Lytton, “Computer modelling of epilepsy,” Nature Reviews Neuroscience, vol. 9, no. 8, pp. 626–637, 2008.