Modelling Coupled Oscillations in the Notch, Wnt, and FGF Signaling Pathways during Somitogenesis: A Comprehensive Mathematical Model

Figure 2

The simulation results of the model. (a) The oscillatory expression of the target genes under the condition of a constant extracellular Wnt and FGF signal. (b) The expression patterns of the target genes after the induction of the Wnt signal to Msgn1 was removed at time point 240 minutes. (c) The expression patterns of the target genes after the induction of the Wnt signal to the Hes7 gene was removed at time point 240 minutes. (d) The expression patterns of the target genes after the FGF protein was removed at time point 240 minutes. (e) The expression patterns of the target genes after the repression of the Hes7 protein to the Dusp4 gene was removed at time point 240 minutes. (f) The expression patterns of the target genes after the repression of the Hes7 protein to the Dll1 gene was removed at time points 240 minutes.

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