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| (1) | Eosinophilic microabscesses (MAB) | Four or more eosinophils clustered together. |
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| (2) | Superficial layering of eosinophils (SLE) | Superficial infiltrate of eosinophils (>1 eosinophil at ×400). |
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| (3) | Epithelial desquamation (ED) | Degenerative (i.e., necrotic, pyknotic-dense, and dark nuclei because of nuclear shrinkage due to irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis, dyskeratotic-deep pink cytoplasm due to abnormal keratinization occurring prematurely within individual cells, or groups of cells below the stratum granulosum) squamous epithelial cells. |
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| (4) | Basal zone hyperplasia (BZH) | Basal cells occupying more than 20% of total mucosal thickness. |
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| (5) | Rete peg elongation (RPE) | Rete peg elongation that reaches at least 2/3 of total mucosal thickness. |
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| (6) | Spongiosis (SP) | Edema or dilated intercellular spaces between epithelial cells. |
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| (7) | Subepithelial fibrosis or lamina propria fibrosis (FB) | Evaluated if lamina propria was present in the specimen; collagen fibrils are densely packed and individual collagen fibrils cannot be distinguished. |
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| (8) | Degree of involvement of eosinophils (DFE) | Focal or diffuse; focal is defined as when eosinophils are localized to one fragment of the biopsy while diffuse is when eosinophils are found >1 fragment of the biopsy. |
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| (9) | Pattern of distribution of eosinophils if present (E-Dist) | Eosinophils confined to or around rete pegs (peripapillary), diffusely distributed, or superficially distributed. |
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| (10) | Eosinophilic degranulation (DE) | Presence of free eosinophil granules. |
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