| Reference | Methods | Sample | Main findings |
| [36] | UPLC-LTQOrbitrap-MS | Serum | The nine metabolites differentiated A-grade from the control group, including nicotinamid e, aminoadipic acid, glutamine, tyramine, dodecenoic acid, lysophosphatidylcholine, glycol-cysteine, cysteine amino acid, and octenoic acid; three metabolites that distinguished grade A from B, including ethanolamine, glycine, glycosylchenodeoxycholic acid; 10 metabolites that differentiated grade B from C, including aminoadipic acid, taurine, aminoacetone, glycine, pyruvate, glycolcholodeoxycholic acid, alanine, pipecolic acid, methionine, and serine. |
| [37] | RP-HPLC-QTOF-MS and HILIC-QTOF-MS | Serum | Oleic acid, bilirubin, acetylcarnitine, and GCDCA were significantly increased in cirrhosis patients and distinguished cirrhosis from control. |
| [38] | GC/MS | Serum | Acetic acid, sorbitol, D-lactic acid, hexanoic acid, 1-naph-thalenamine, butanoic acid, phosphoric acid, D-glucitol, and glucose were the strongest segregation between cirrhosis and CHB. |
| [39] | 1H-NMR | Serum | Compared with the compensatory period, some metabolites increased significantly, including glucose, citrate, succinate, phenylalanine, tyrosine, lysine, glutamine, and creatine, whereas some decreased notably, namely, LDL, VLDL, N-acyl glycoprotein (NAG), choline, acetone, isoleucine, and valine in the decompensation period. |
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