Research Article
The Effect of Antidepressants on the Course of Inflammatory Bowel Disease
Table 2
Effect of antidepressant use on subsequent development of IBD activity and according to anxiety and depression scores at baseline.
| | Antidepressant Use: All Patients | Antidepressant Use: Normal Anxiety and Depression Scores at Baseline | Antidepressant Use: Abnormal Anxiety or Depression Scores at Baseline | Antidepressant Use: Abnormal Anxiety Scores at Baseline | Antidepressant Use: Abnormal Depression Scores at Baseline | No | Yes | P value | No | Yes | P value | No | Yes | P value | No | Yes | P value | No | Yes | P value |
| Glucocorticosteroid prescription or flare of disease activity () | 121/279 (43.4) | 21/52 (40.4) | 0.69 | 82/203 (40.4) | 10/25 (40.0) | 0.97 | 38/73 (52.1) | 11/27 (40.1) | 0.32 | 35/65 (53.8) | 10/26 (38.5) | 0.19 | 9/21 (42.9) | 6/14 (42.9) | 1.00 |
| Escalation of medical therapy in response to uncontrolled disease activity () | 120/279 (43.0) | 17/52 (32.7) | 0.17 | 85/203 (41.9) | 10/25 (40.0) | 0.86 | 34/73 (46.6) | 7/27 (25.9) | 0.06 | 31/65 (47.7) | 6/26 (23.1) | 0.03 | 8/21 (38.1) | 5/14 (35.7) | 0.89 |
| Hospitalisation due to disease activity () | 38/279 (13.6) | 5/52 (9.6) | 0.43 | 26/203 (12.8) | 4/25 (16.0) | 0.66 | 12/73 (16.4) | 1/27 (3.7) | 0.09 | 11/65 (16.9) | 1/26 (3.8) | 0.10 | 2/21 (9.5) | 0/14 (0) | 0.23 |
| Intestinal resection () | 15/279 (5.4) | 4/52 (7.7) | 0.51 | 8/203 (3.9) | 3/25 (12.0) | 0.08 | 7/73 (9.6) | 1/27 (3.7) | 0.34 | 6/65 (9.2) | 1/26 (3.8) | 0.38 | 2/21 (9.5) | 0/14 (0) | 0.23 |
| Any adverse outcome () | 148/279 (53.0) | 24/52 (46.2) | 0.36 | 102/203 (50.2) | 12/25 (48.0) | 0.83 | 45/73 (61.6) | 12/27 (44.4) | 0.12 | 42/65 (64.6) | 11/26 (42.3) | 0.05 | 10/21 (47.6) | 6/14 (42.9) | 0.78 |
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