Research Article
The Effect of Antidepressants on the Course of Inflammatory Bowel Disease
Table 3
Effect of antidepressant or SSRI use on subsequent IBD activity based on univariate cox regression analysis.
| | Glucocorticosteroid prescription or flare of disease activity | Escalation of Medical Therapy in Response to Uncontrolled Disease Activity | Hospitalisation due to Disease Activity | Intestinal resection | | Hazard ratio (95 CI) | P value | Hazard ratio (95 CI) | P value | Hazard ratio (95 CI) | P value | Hazard ratio (95 CI) | P value |
| Antidepressant use: all patients | 0.76 (0.47-1.22) | 0.25 | 0.59 (0.35-1.00) | 0.05 | 0.59 (0.231.50) | 0.26 | 1.15 (0.373.53) | 0.81 |
| Antidepressant use: normal anxiety and depression scores at baseline | 0.77 (0.38-1.54) | 0.77 | 0.72 (0.36-1.44) | 0.35 | 1.01 (0.352.93) | 0.98 | 2.15 (0.558.50) | 0.27 |
| Antidepressant use: abnormal anxiety or depression scores at baseline | 0.63 (0.32-1.23) | 0.17 | 0.47 (0.21-1.05) | 0.07 | 0.20 (0.031.57) | 0.13 | 0.37 (0.053.04) | 0.36 |
| SSRI use: all patients | 0.74 (0.41-1.31) | 0.30 | 0.47 (0.24-0.93) | 0.03 | 0.35 (0.081.46) | 0.15 | 0.86 (0.193.85) | 0.84 |
| SSRI use: normal anxiety and depression scores at baseline | 0.76 (0.31-1.91) | 0.56 | 0.49 (0.18-1.37) | 0.18 | 0.87 (0.203.75) | 0.86 | 2.39 (0.4712.2) | 0.29 |
| SSRI use: abnormal anxiety or depression scores at baseline | 0.58 (0.27-1.26) | 0.17 | 0.43 (0.17-1.11) | 0.08 | 0.03 (0.0010.1) | 0.24 | 0.03 (0.0073.9) | 0.39 |
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