Review Article

The Use of Biomarkers in Early Diagnostics of Pancreatic Cancer

Table 1

Overview of biomarkers of early pancreatic cancer.

Traditional biomarkersCA 19-9, CEA

ProteomicsCEMIP, C4BPA, IGFBP2, IGFBP3

MetabolitesM2-pyruvate kinase (M2-PK), palmitic acid, glucitol, xylitol, inositol, histidine, proline, sphingomyelin, phosphatidylcholine, isocitrate, ceramide

Antibodiesimmunoglobulin G4 (IgG4)

Cytokinesinterleukin-1β, interleukin-6, interleukin-8, interleukin-10, vascular endothelial growth factor and transforming growth factor (macrophage inhibitory cytokine-1 [MIC-1])

Noncoding RNAs (ncRNAs)microRNAs (miRNAs), small ncRNAs (sncRNAs), long ncRNAs (lncRNAs)

Liquid biopsycirculating tumor cells (CTCs), circulation tumor DNA (ctDNA) and exosomes

Body fluidsdetecting biomarkers from saliva, urine, stool or pancreatic juice