Gastric Cancer Cell Lines Have Different MYC-Regulated Expression Patterns but Share a Common Core of Altered Genes

Table 3

Enriched hallmark gene sets for DEGs after MYC-siRNa in three GC cell lines.

Hallmark Name:	Process category	Description	Size^∗	ES	NES	Nom. P-value	FDR	Max. Rank
MYC_TARGETS_V1	Proliferation	MYC targets, variant 1	100/44	0.59	1.89	0.00	0.000	1368
REACTIVE_OXIGEN_SPECIES_PATHWAY	Pathway	Reactive oxygen species pathway	25/13	0.55	1.42	0.00	0.000	2316
UNFOLDED_PROTEIN_RESPONSE	Pathway	Unfolded protein response; ER stress	50/22	0.55	1.56	0.00	0.000	1891
PROTEIN_SECRETION	Pathway	Protein secretion	44/26	0.55	1.70	0.00	0.000	2376
G2M_CHECKPOINT	Proliferation	Cell cycle progression: G2/M checkpoint	97/40	0.52	1.67	0.00	0.000	1813
MTORC1_SIGNALING	Signaling	mTORC1 signaling	102/43	0.50	1.46	0.00	0.044	2021
E2F_TARGETS	Proliferation	Cell cycle progression: E2F targets	89/35	0.48	1.42	0.00	0.052	1607
OXIDATIVE_PHOSPHORYLATION	Metabolic	Oxidative phosphorylation and citric acid cycle	118/57	0.48	1.46	0.00	0.062	2284
CHOLESTEROL_HOMEOSTASIS	Metabolic	Cholesterol homeostasis	39/14	0.48	1.48	0.00	0.069	1671
DNA_REPAIR	DNA damage	DNA repair	80/38	0.46	1.42	0.00	0.077	2337
APOPTOSIS	Pathway	Programmed cell death; caspase pathway	66/29	0.42	1.31	0.20	0.190	2405

of genes found for each gene set after curating data. ES: enrichment score. NES: normalized enrichment score. Nom. P-value: nominal P-values for each gene set. FDR: false discovery rate. Max. rank: maximum rank numbers for each gene sets.